Title:
ＩＲＡＫ阻害剤としてのヘテロアリール化合物及びその使用
Document Type and Number:
Japanese Patent JP6835828
Kind Code:
B2
Abstract:
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
Inventors:
Catherine Jolan-Le Blanc
Luokushi Ran
Austin Chen
Ryan C. Clark
Luokushi Ran
Austin Chen
Ryan C. Clark
Application Number:
JP2018513803A
Publication Date:
February 24, 2021
Filing Date:
September 16, 2016
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07D401/04; A61K31/4184; A61K31/4196; A61K31/422; A61K31/4439; A61K31/496; A61K31/497; A61K31/4995; A61K31/501; A61K31/506; A61K31/5355; A61K31/5377; A61K31/5386; A61K31/541; A61K31/551; A61K31/553; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P13/10; A61P13/12; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/16; A61P25/28; A61P31/04; A61P35/00; A61P37/02; A61P43/00; C07D403/04; C07D413/04; C07D413/14; C07D417/04; C07D417/14; C07D471/18; C07D487/18; C07D498/18
Domestic Patent References:
| JP2005532251A | ||||
| JP2014533286A | ||||
| JP2013532726A | ||||
| JP2012525390A | ||||
| JP2012525389A | ||||
| JP2010504980A | ||||
| JP2012046541A | ||||
| JP2013512952A | ||||
| JP11100368A | ||||
| JP2013522364A |
Foreign References:
| WO2005079791A1 | ||||
| WO2010126922A1 | ||||
| WO2014121931A1 |
Other References:
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US,2011年12月 4日,Retrieved from STN,Database accession no. RN 1348016-33-0,N-[1-(2-hydroxy-2-methylpropyl)-5-(2-oxo-1-pyrrolidinyl)-1H-benzimidazol-2-yl]-5-(2-methyl-5-oxazolyl)-2-Thiophenecarboxamide
De Nanteuil, Guillaume; Portevin, Bernard; Fradin, Armel; Bonnet, Jacqueline,5-imidazol-1-yl-1H-benzimidazoles as Interleukin-1 inhibitors: a key approach in the search of new treatments for osteoarthritis,Actualite Chimique,2000年,48-54
Buckley G M.,et.al.,IRAK-4 inhibitors. Part III : A series of imidazo[1,2-a]pyridines,Bioorganic & Medicinal Chemistry Letters,2008年,18(12),3656-3660
De Nanteuil, Guillaume; Portevin, Bernard; Fradin, Armel; Bonnet, Jacqueline,5-imidazol-1-yl-1H-benzimidazoles as Interleukin-1 inhibitors: a key approach in the search of new treatments for osteoarthritis,Actualite Chimique,2000年,48-54
Buckley G M.,et.al.,IRAK-4 inhibitors. Part III : A series of imidazo[1,2-a]pyridines,Bioorganic & Medicinal Chemistry Letters,2008年,18(12),3656-3660
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takahide Sasaki