Title:
HETEROARYL COMPOUNDS FOR KINASE INHIBITION
Document Type and Number:
Japanese Patent JP2023052388
Kind Code:
A
Abstract:
To provide heteroaryl compounds for kinase inhibition.SOLUTION: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein. Compounds that are capable of inhibiting mutant EGFR proteins, e.g., EGFR having one or more mutations in the exon 20 domain are also described herein. In some embodiments, compounds disclosed herein selectively inhibit mutant EGFR, such as EGFR having one or more exon 20 mutations, in comparison to a wild-type EGFR.SELECTED DRAWING: None
Inventors:
Wei-Sheng Huang
Gon Youngjin
Li Feng
Nicholas E. Bencivenga
David C. Dalgarno
Anna Coleman
William See. Shakespeare
Lanny M. Thomas
Angela buoy. Waist
Wilmen Youngsay
Zhang Yun
tianjun elephant
Xiaotian Zoo
Gon Youngjin
Li Feng
Nicholas E. Bencivenga
David C. Dalgarno
Anna Coleman
William See. Shakespeare
Lanny M. Thomas
Angela buoy. Waist
Wilmen Youngsay
Zhang Yun
tianjun elephant
Xiaotian Zoo
Application Number:
JP2023003712A
Publication Date:
April 11, 2023
Filing Date:
January 13, 2023
Export Citation:
Assignee:
Takeda GmbH
International Classes:
A61K31/506; A61K31/53; A61K31/5355; A61K31/66; A61P35/00; A61P43/00; C07D401/14; C07D403/04; C07D405/14; C07D471/04; C07F9/53
Attorney, Agent or Firm:
Shusaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Previous Patent: Peptide for treatment of rheumatoid arthritis and use thereof
Next Patent: cart for transportation
Next Patent: cart for transportation