Title:
α4インテグリンによって媒介される白血球接着を阻害するヘテロアリール化合物
Document Type and Number:
Japanese Patent JP4413135
Kind Code:
B2
Abstract:
Disclosed are compounds which bind alpha4 integrins, where the alpha4 integrin is preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by alpha4 integrins, where the alpha4 integrin is preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Inventors:
Conrad, Andrew W.
Semco, Christopher M.
Shoe, In-Gee
Stappenbeck, Frank
Stupy, Brian Pee.
Smith, jennifer
Solset, Eugene Dee.
Place, Michael A.
Semco, Christopher M.
Shoe, In-Gee
Stappenbeck, Frank
Stupy, Brian Pee.
Smith, jennifer
Solset, Eugene Dee.
Place, Michael A.
Application Number:
JP2004506758A
Publication Date:
February 10, 2010
Filing Date:
May 27, 2003
Export Citation:
Assignee:
Elan Pharmaceuticals, Inc.
International Classes:
C07D239/69; A61K31/505; A61P19/02; A61P29/00; A61P43/00; C07D239/48; C07D239/50
Foreign References:
| WO2002008201A2 | ||||
| WO2000043372A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita