HETEROARYL-PYRIMIDINE DERIVATIVE AS JAK INHIBITOR

Title:

HETEROARYL-PYRIMIDINE DERIVATIVE AS JAK INHIBITOR

Document Type and Number:

Japanese Patent JP2011016839

Kind Code:

A

Abstract:

To provide inhibitors of JAK, JNK, CDK and ZAP-70 protein kinase, useful in treatment of various diseases and disorders associated with activity of JAK, JNK, CDK and ZAP-70.

There are provided compositions containing a compound of formula (IVa) or a pharmaceutically permissible salt thereof and methods utilizing the compositions in disorders mediated by various protein kinases.

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Inventors:

BETHIEL RANDY S
LEDEBOER MARK

Application Number:

JP2010211038A

Publication Date:

January 27, 2011

Filing Date:

September 21, 2010

Export Citation:

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Assignee:

VERTEX PHARMA

International Classes:

A61K31/538; A61P9/00; A61P11/06; A61P19/02; A61P21/00; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D403/04; C07D413/04; C07D413/14

Foreign References:

WO2002079197A1	2002-10-10
WO2002020495A2	2002-03-14
WO2001062233A2	2001-08-30

Attorney, Agent or Firm:

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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