Title:
HETEROCYCLIC ASPARTYL PROTEASE INHIBITOR
Document Type and Number:
Japanese Patent JP2008174570
Kind Code:
A
Abstract:
To provide an aspartyl protease inhibitor.
Disclosed are compounds of the formula (I). Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds in combination with a cholinesterase inhibitor or a muscarinic antagonist.
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Inventors:
ZHU ZHAONING
MCKITTRICK BRIAN
SUN ZHONG-YUE
YE YUANZAN C
VOIGT JOHANNES H
STRICKLAND COREY
SMITH ELIZABETH M
STAMFORD ANDREW
GREENLEE WILLIAM J
WU YUSHENG
ISERLOH ULRICH
MAZZOLA ROBERT
CALDWELL JOHN
CUMMING JARED
WANG LINGYAN
GUO TAO
LE THUY X H
SAIONZ KURT W
BABU SURESH D
HUNTER RACHAEL C
MCKITTRICK BRIAN
SUN ZHONG-YUE
YE YUANZAN C
VOIGT JOHANNES H
STRICKLAND COREY
SMITH ELIZABETH M
STAMFORD ANDREW
GREENLEE WILLIAM J
WU YUSHENG
ISERLOH ULRICH
MAZZOLA ROBERT
CALDWELL JOHN
CUMMING JARED
WANG LINGYAN
GUO TAO
LE THUY X H
SAIONZ KURT W
BABU SURESH D
HUNTER RACHAEL C
Application Number:
JP2008079293A
Publication Date:
July 31, 2008
Filing Date:
March 25, 2008
Export Citation:
Assignee:
SCHERING CORP
PHARMACOPEIA DRUG DISCOVERY
PHARMACOPEIA DRUG DISCOVERY
International Classes:
C07D233/88; A61K31/4164; A61K31/4168; A61K31/4178; A61K31/4184; A61K31/422; A61K31/4245; A61K31/428; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4725; A61K31/496; A61K31/513; A61K31/5377; A61P9/12; A61P13/12; A61P25/28; A61P31/10; A61P31/18; A61P33/00; A61P33/06; A61P35/00; A61P43/00; C07D235/02; C07D239/22; C07D239/47; C07D271/06; C07D271/07; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D403/12; C07D403/14; C07D405/04; C07D405/06; C07D405/10; C07D405/12; C07D405/14; C07D407/14; C07D409/04; C07D409/06; C07D409/10; C07D409/14; C07D413/06; C07D413/12; C07D413/14; C07D417/12
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita