Title:
HETEROCYCLIC COMPOUND FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATION
Document Type and Number:
Japanese Patent JP2010100640
Kind Code:
A
Abstract:
To provide a new five-membered heterocyclic compound useful for treating and/or preventing diabetes and diabetes-related diseases.
The invention discloses the followings: a compound expressed by formula (1) and salts thereof; a method for producing them; their therapeutic and cosmetic applications particularly in the management of aging-related and diabetic vascular complications; an AGE (Advanced Glycation End product) breaker, an AGE inhibitor and a free radical scavenger; pharmaceuticals and cosmetic compositions comprising these compounds; and a method of treating diseases caused by accumulation of AGE and/or free radicals in the body cells.
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Inventors:
SANKARANARAYANAN ALANGUDI
Application Number:
JP2009295336A
Publication Date:
May 06, 2010
Filing Date:
December 25, 2009
Export Citation:
Assignee:
TORRENT PHARMACEUTICALS LTD
International Classes:
C07D401/04; A61K8/00; A61K8/49; A61K31/4427; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61P1/00; A61P1/04; A61P1/16; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/10; A61P17/10; A61P17/16; A61P19/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/12; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P39/06; A61P43/00; A61Q5/00; A61Q17/04; A61Q19/00; A61Q19/08; C07D401/14; C07D405/14; C07D409/00; C07D409/04; C07D409/14; C07D411/04; C07D413/04; C07D413/14
Domestic Patent References:
| JPS4931989B1 | 1974-08-27 | |||
| JPH0649045A | 1994-02-22 | |||
| JPS6422869A | 1989-01-25 | |||
| JPH09291082A | 1997-11-11 | |||
| JP2004529154A | 2004-09-24 |
Foreign References:
| US3501312A | 1970-03-17 | |||
| WO1999025690A2 | 1999-05-27 | |||
| WO2000051987A2 | 2000-09-08 | |||
| WO2001025208A1 | 2001-04-12 | |||
| WO2001025209A1 | 2001-04-12 | |||
| US5330994A | 1994-07-19 | |||
| WO1998056785A1 | 1998-12-17 | |||
| US3957805A | 1976-05-18 |
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JPN6008020588; Ｒａｍ， Ｖｉｓｈｎｕ Ｊｉ: 'Ｒｉｎｇ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｒｅａｃｔｉｏｎｓ． Ｉ． Ｃｏｎｖｅｒｓｉｏｎ ｏｆ ６-ａｒｙｌ-４-（ｍｅｔｈｙｌｔｈｉｏ）-２- ｏｘｏ-２Ｈ-ｐｙｒａｎ-３-ｃａｒｂｏｎｉｔｒｉ' Ｌｉｅｂｉｇｓ Ａｎｎａｌｅｎ ｄｅｒ Ｃｈｅｍｉｅ Ｎｏ．１１, 1991, ｐｐ．１２２９-１２３１
JPN6008020589; Ｂｅｌｇｏｄｅｒｅ， Ｅｌｅｎａ: 'Ｈｅｔｅｒｏｃｙｃｌｅｓ' Ｓｔｕｄｉｅｓ ｏｎ ｉｓｏｍｅｒｉｃ ｐｙｒｉｄｙｌｉｓｏｘａｚｏｌｅｓ Ｖｏｌ．２０，Ｎｏ．３, 1983, ｐｐ．５０１-５０４
JPN6008020584; Ｗｕ， Ｆｅｉｙｕｅ: 'Ｐｒｅｐａｒａｔｉｏｎ ａｎｄ Ｓｔｕｄｙ ｏｆ Ｔａｕｔｏｍｅｒｓ Ｄｅｒｉｖｅｄ ｆｒｏｍ ２-（２'-Ｐｙｒｉｄｙｌ）ｉｎｄｏｌｅ ａｎｄ Ｒｅｌａｔｅｄ Ｃｏｍｐｏｕｎｄｓ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６３，Ｎｏ．１２, 1998, ｐｐ．４０５５-４０６１
JPN6008020582; Ｇｉａｒｄ， Ｔｈｉｅｒｒｙ: 'Ｐｙｒｒｏｌｉｄｉｎｅｓ ｂｅａｒｉｎｇ ａ ｑｕａｔｅｒｎａｒｙ alpha-ｓｔｅｒｅｏｇｅｎｉｃ ｃｅｎｔｅｒ． Ｐａｒｔ １． Ｓｙｎｔｈｅｓｉｓ ｏｆ ａｎａｌｏｇｓ ｏｆ ＡＢＴ-４１８， ａ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４０，Ｎｏ．３０, 1999, ｐｐ．５４９５-５４９７
JPN6008020586; Ｆｅｒｌｅｓ， Ｍｉｌｏｓｌａｖ: 'Ｓｔｕｄｉｅｓ ｉｎ ｔｈｅ ｐｙｒｉｄｉｎｅ ｓｅｒｉｅｓ． ＬＩＶ． Ｒｅａｃｔｉｏｎ ｏｆ １-ｐｙｒｉｄｙｌ-１，３- ｂｕｔａｎｅｄｉｏｎｅｓ ａｎｄ １，３-ｄｉｐｙｒｉｄｙｌ-１，３' Ｃｏｌｌｅｃｔｉｏｎ ｏｆ Ｃｚｅｃｈｏｓｌｏｖａｋ Ｃｈｅｍｉｃａｌ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．４６，Ｎｏ．５, 1981, ｐｐ．１１６７-１１７２
JPN6008020588; Ｒａｍ， Ｖｉｓｈｎｕ Ｊｉ: 'Ｒｉｎｇ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｒｅａｃｔｉｏｎｓ． Ｉ． Ｃｏｎｖｅｒｓｉｏｎ ｏｆ ６-ａｒｙｌ-４-（ｍｅｔｈｙｌｔｈｉｏ）-２- ｏｘｏ-２Ｈ-ｐｙｒａｎ-３-ｃａｒｂｏｎｉｔｒｉ' Ｌｉｅｂｉｇｓ Ａｎｎａｌｅｎ ｄｅｒ Ｃｈｅｍｉｅ Ｎｏ．１１, 1991, ｐｐ．１２２９-１２３１
JPN6008020589; Ｂｅｌｇｏｄｅｒｅ， Ｅｌｅｎａ: 'Ｈｅｔｅｒｏｃｙｃｌｅｓ' Ｓｔｕｄｉｅｓ ｏｎ ｉｓｏｍｅｒｉｃ ｐｙｒｉｄｙｌｉｓｏｘａｚｏｌｅｓ Ｖｏｌ．２０，Ｎｏ．３, 1983, ｐｐ．５０１-５０４
Attorney, Agent or Firm:
Narumi Morishima