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Patent Searching and Data


Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
Japanese Patent JPH0358978
Kind Code:
A
Abstract:

NEW MATERIAL: A compound represented by formula I [wherein A taken together with the two carbon atoms denoted as α and β is formula II or formula III (wherein R8 denotes halogen, alkyl, and the like; and R9 denotes H, halogen, and the like), and the like; the dotted line denotes the double bond; n denotes 0, 1, 2, or 3; one of R1 and R2 is carboxyl or alkoxycarbonyl and the other is H; R3 is H, alkyl, alkoxyl, and the like; an R4 to R7 are H, alkyl, and the like], and salts of the compounds of formula I in which one of R1 and R2 is carboxyl and the other is H with bases.

EXAMPLE: (+)-3-(4-Chlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohepto[d]isoxazole-6- carboxylic acid.

USE: Medicaments for the treatment of rheumatoid arthritis, inflammatory respiratory diseases, shock and the like.

PROCESS: A compound represented by formula I is obtained by reacting a novel compound represented by formula IV (wherein one of R1a and R2a is alkoxycarbonyl, and the other is H; and R3a is H or alkyl) and either of pyridine bromide perbromate or chromic acid.


Inventors:
Lawton, Geoffrey
Osbond, John M.
Self, Christopher R.
Application Number:
JP1990000189572
Publication Date:
March 14, 1991
Filing Date:
July 19, 1990
Export Citation:
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Assignee:
F HOFFMANN LA ROCHE AG
International Classes:
A61K31/42; A61K31/423; A61K31/425; A61K31/428; A61P29/00; C07C225/18; C07C225/20; C07D261/20; C07D275/04; C07D295/155; C07F7/18; (IPC1-7): A61K31/42; A61K31/425; C07D261/20; C07D275/04; C07F7/18