NEW MATERIAL:The compound of formula I [R is H, alkyl, amidino, guanidino, or group of formula II (x is 0W4; R1 and R2 are H, alkyl or together with N form a 5- or 6-membered heterocyclic group); X and Y are NH, O or S; m is 0W4; n is 1W6; Z is group of formula III(W is NH or CH2; Q is NH, N-CN, CH-NO2, etc.; R3 and R4 are H, alkyl, etc.), group of formula IV (G is CH or N; R5 is H, alkyl, etc.), etc.], its salt, its hydrate or its solvate.
EXAMPLE: N-Cyano-N'-methyl-N"-{3-[ 5-( 2-dimethylaminomethylbenzimidazolyl )-oxy]propyl}guanidine.
USE: An agent for suppressing the gastric juice secretion. Useful for the remedy of peptic ulcer.
PROCESS: For example, the compond of formula I wherein Z is group of formula III can be prepared by reacting the novel compound of formula V with the compound of formula VI (R30 is alkyl; A is O or S), and reacting the resultant compond with an amine of formula HNR3R4.
NOHARA FUJIO
FUJINAWA TOMOAKI
OGAWA KAZUO
MIZUKAMI TERUO
SHIRAI SHIYUNICHI
