Title:
PI3K活性の阻害剤としての複素環化合物及びその使用
Document Type and Number:
Japanese Patent JP2013530238
Kind Code:
A
Abstract:
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with pi 110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
Inventors:
Buoy, Mina Hue Tan
Fisher, Benjamin
Hao, Xiaolin
Lucas, Bryan
Fisher, Benjamin
Hao, Xiaolin
Lucas, Bryan
Application Number:
JP2013518692A
Publication Date:
July 25, 2013
Filing Date:
June 30, 2011
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
C07D401/06; A61K31/4709; A61K31/506; A61K31/5377; A61P1/00; A61P7/02; A61P7/04; A61P7/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/10; A61P17/02; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D401/14; C07D405/14; C07D413/14
Attorney, Agent or Firm:
Kawaguchi International Patent Office