NEW MATERIAL: A compound of formula I (Ar1 is (substd.)phenyl or (substd.) naphthyl; A1 is C1-6 alkylene, C3-6 alkenylene, etc.: Ar2 is (substd.)phenylene or 6-membered heterocyclic moiety containing up to three N atoms; R1 is H, C1-6 alkyl, C3-6 alkenyl, etc.; R2 and R3 together form -A2-X-A3- (A2 and A3 are each C1-4 alkylene; X is oxy, thio, sulfinyl, etc.)].
EXAMPLE: 4-methoxy-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyrane.
USE: This compound is useful for treatment of inflammation and allergic diseases, because it exhibits 5-lipoxygenase inhibition.
PROCESS: A compound of formula II is reacted with a compound of the formula Ar1-A1Z (Z is a group capable of being substituted, e.g. halogen, sulfonyloxy, etc.), in a solvent such as N,N-dimethylformamide or the like in the presence of a base (e.g. sodium carbonate) at 10-150°C to give the compound of formula I.
JIYANNMAARU MARII MOORISU JIRO
ICI PLC
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