Title:
神経変性疾患の治療において用いられる複素環誘導体
Document Type and Number:
Japanese Patent JP2011528335
Kind Code:
A
Abstract:
The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr-X-CHR1R2 (I) in which: -HetAr represents a group chosen from: -X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an -NH- or -NH-CO- group, -R1 represents a hydrogen atom or an -OH, -O(C1-C6)alkyl, -OCO((C1-C6)alkyl), -OSO2((C1-C6)alkyl) or -OSO3H group, and -R2 represents a hydrogen atom or a (C2-C6)alkynyl, (C2-C6)alkenyl or (C3-C6)cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases.
Inventors:
Schmidt Funny
Figadere Bruno
Bozari Rita Sylvia
Champy Pierre
Frank xavier
Figadere Bruno
Bozari Rita Sylvia
Champy Pierre
Frank xavier
Application Number:
JP2011517959A
Publication Date:
November 17, 2011
Filing Date:
July 20, 2009
Export Citation:
Assignee:
Centr National de la Surche Scientific (CNR)
International Classes:
C07D215/14; A61K31/47; A61K31/498; A61P9/10; A61P25/00; A61P25/16; A61P25/28; C07D241/42
Domestic Patent References:
| JPH0930960A | 1997-02-04 | |||
| JPH01160963A | 1989-06-23 |
Foreign References:
| CN1966500A | 2007-05-23 | |||
| US20050165052A1 | 2005-07-28 | |||
| FR781812A | 1935-05-22 |
Other References:
JPN6013059566; Ｆａｋｈｆａｋｈ， Ｍ．Ａ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ｓｕｂｓｔｉｔｕｔｅｄ ｑｕｉｎｏｌｉｎｅｓ： ｐｏｔｅｎｔｉａｌ ｔｒｅａｔｍｅｎｔ ｏｆ ｐｒｏｔｏｚｏａｌ ａｎｄ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ １１（２３）, 2003, ｐ．５０１３-５０２３
JPN6013059567; Ｆｏｕｒｎｅｔ， Ａ． ｅｔ ａｌ．: 'Ｓｕｂｓｔｉｔｕｔｅｄ ｑｕｉｎｏｌｉｎｅｓ ｉｎｄｕｃｅ ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｐｒｏｌｉｆｅｒａｔｉｏｎ ｏｆ ＨＴＬＶ-１ ｉｎｆｅｃｔｅｄ ｃｅｌｌｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ １３（５）, 2003, ｐ．８９１-８９４
JPN5012004508; ＨＵＩ: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＴＩＰＲＯＴＯＺＯＡＬ ＡＣＴＩＶＩＴＹ ＯＦ ＳＯＭＥ ＮＥＷ ＳＹＮＴＨＥＴＩＣ ＳＵＢＳＴＩＴＵＴＥＤ ＱＵＩＮＯＸＡＬＩＮＥＳ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖ１６ Ｎ４, 20060215, Ｐ８１５-８２０, ＰＥＲＧＡＭＯＮ， ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ
JPN6013059570; Ｄｕｒｅｔ， Ｐ． ｅｔ ａｌ．: 'Ｐｒｅｐａｒａｔｉｖｅ ｓｅｐａｒａｔｉｏｎ ｏｆ ｑｕｉｎｏｌｉｎｅｓ ｂｙ ｃｅｎｔｒｉｆｕｇａｌ ｐａｒｔｉｔｉｏｎ ｃｈｒｏｍａｔｏｇｒａｐｈｙ ｗｉｔｈ ｇｒａｄｉｅｎｔ ｅｌｕｔｉｏｎ' Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ， Ａ １０１１（１-２）, 2003, ｐ．５５-６５
JPN5012004506; ＧＡＵＴＩＥＲ Ｊ Ａ: '２-ＱＵＩＮＯＬＹＬＡＬＫＹＮＥＳ． ＩＩ． ＱＵＩＮＯＬＩＮＥＳ ＷＩＴＨ ＭＵＬＴＩＰＬＥ ＦＵＮＣＴＩＯＮＳ ＦＲＯＭ ＭＯＮＯＳＵＢＳＴＩＴＵＴＥＤ ＱＵＩＮＯＬＹＬＡＬＫＹＮＥＳ' ＢＵＬＬＥＴＩＮ ＤＥ ＬＡ ＳＯＣＩＥＴＥ ＣＨＩＭＩＱＵＥ ＤＥ ＦＲＡＮＣＥ , 19610101, Ｐ２０９８-２１０９, ＳＯＣＩＥＴＥ ＦＲＡＮＣＡＩＳＥ ＤＥ ＣＨＩＭＩＥ
JPN5012004507; ＲＥＮＡＵＬＴ Ｊ: 'ＳＥＣＯＮＤＡＲＹ ＡＭＩＮＯＱＵＩＮＯＬＥＩＮＥＳ ＷＩＴＨ ＰＯＴＥＮＴＩＡＬ ＡＭＥＢＩＣＩＤＥ ＡＣＴＩＶＩＴＹ： 以下備考' ＣＯＭＰＴＥＳ ＲＥＮＤＵＳ ＨＥＢＤＯＭＡＤＡＩＲＥＳ ＤＥＳ ＳＥＡＮＣＥＳ ＤＥ Ｌ'ＡＣＡＤＥＭＩＥ ＤＥＳ ＳＣＩＥＮＣＥＳ． ＳＥＲＩＥＳ Ｄ Ｖ２８２ Ｎ５, 19760202, Ｐ５０９-５１１, ＳＣＩＥＮＣＥＳ ＮＡＴＵＲＥＬＬＥＳ
JPN6013059567; Ｆｏｕｒｎｅｔ， Ａ． ｅｔ ａｌ．: 'Ｓｕｂｓｔｉｔｕｔｅｄ ｑｕｉｎｏｌｉｎｅｓ ｉｎｄｕｃｅ ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｐｒｏｌｉｆｅｒａｔｉｏｎ ｏｆ ＨＴＬＶ-１ ｉｎｆｅｃｔｅｄ ｃｅｌｌｓ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ １３（５）, 2003, ｐ．８９１-８９４
JPN5012004508; ＨＵＩ: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＡＮＴＩＰＲＯＴＯＺＯＡＬ ＡＣＴＩＶＩＴＹ ＯＦ ＳＯＭＥ ＮＥＷ ＳＹＮＴＨＥＴＩＣ ＳＵＢＳＴＩＴＵＴＥＤ ＱＵＩＮＯＸＡＬＩＮＥＳ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖ１６ Ｎ４, 20060215, Ｐ８１５-８２０, ＰＥＲＧＡＭＯＮ， ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ
JPN6013059570; Ｄｕｒｅｔ， Ｐ． ｅｔ ａｌ．: 'Ｐｒｅｐａｒａｔｉｖｅ ｓｅｐａｒａｔｉｏｎ ｏｆ ｑｕｉｎｏｌｉｎｅｓ ｂｙ ｃｅｎｔｒｉｆｕｇａｌ ｐａｒｔｉｔｉｏｎ ｃｈｒｏｍａｔｏｇｒａｐｈｙ ｗｉｔｈ ｇｒａｄｉｅｎｔ ｅｌｕｔｉｏｎ' Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ， Ａ １０１１（１-２）, 2003, ｐ．５５-６５
JPN5012004506; ＧＡＵＴＩＥＲ Ｊ Ａ: '２-ＱＵＩＮＯＬＹＬＡＬＫＹＮＥＳ． ＩＩ． ＱＵＩＮＯＬＩＮＥＳ ＷＩＴＨ ＭＵＬＴＩＰＬＥ ＦＵＮＣＴＩＯＮＳ ＦＲＯＭ ＭＯＮＯＳＵＢＳＴＩＴＵＴＥＤ ＱＵＩＮＯＬＹＬＡＬＫＹＮＥＳ' ＢＵＬＬＥＴＩＮ ＤＥ ＬＡ ＳＯＣＩＥＴＥ ＣＨＩＭＩＱＵＥ ＤＥ ＦＲＡＮＣＥ , 19610101, Ｐ２０９８-２１０９, ＳＯＣＩＥＴＥ ＦＲＡＮＣＡＩＳＥ ＤＥ ＣＨＩＭＩＥ
JPN5012004507; ＲＥＮＡＵＬＴ Ｊ: 'ＳＥＣＯＮＤＡＲＹ ＡＭＩＮＯＱＵＩＮＯＬＥＩＮＥＳ ＷＩＴＨ ＰＯＴＥＮＴＩＡＬ ＡＭＥＢＩＣＩＤＥ ＡＣＴＩＶＩＴＹ： 以下備考' ＣＯＭＰＴＥＳ ＲＥＮＤＵＳ ＨＥＢＤＯＭＡＤＡＩＲＥＳ ＤＥＳ ＳＥＡＮＣＥＳ ＤＥ Ｌ'ＡＣＡＤＥＭＩＥ ＤＥＳ ＳＣＩＥＮＣＥＳ． ＳＥＲＩＥＳ Ｄ Ｖ２８２ Ｎ５, 19760202, Ｐ５０９-５１１, ＳＣＩＥＮＣＥＳ ＮＡＴＵＲＥＬＬＥＳ
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto