Title:
複素環式非ペプチドGNRH拮抗薬
Document Type and Number:
Japanese Patent JP2008543965
Kind Code:
A
Abstract:
A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, -CN, -C(Rc)2OH, -N(Rd)C(-X)Rc, -C(-X)N(Rc)(Rd), -S(O)m-Rc, -N(Rc)(Rd)S(O)2, -S(O)2N(Rc)(Rd), -N(Rc)2, aryl optionally substituted with Ra or -O-aryl optionally substituted with Ra; or B is present and is -(CH2)n-, -C(Rb)2- or -O-, or B taken together with A or Z can be -C-C(Rb)-, -C(Rb)-C-, -CH2-CH(Rb)- or -CH(Rb)-CH2-; D is -O- or -S(O)m'-; E is a bond or is -(CH2)n-, -N(Rd)-, -(CH2)nN(Rd)- or -N(Rd)(CH2)n-; F is -C(-X)-; G is -(CH2)n-, -N(Rd)-, -(CH2)nN(Rd)- or -N(Rd)(CH2)n; J is a bond, -O-, -N(RC)C(-X)-, -C(-X)N(Rc)-, -S(O)m'-, -N(Rc)S(O)m-, -S(O)nN(Rc)-, -N(Rc)- or -N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.
Inventors:
Graham Andrew Showwell
David John Miller
Angela glen
Maria Angels Cubillo de Dios
Kevin Merchant
Ajay Kumar Mandal
David John Miller
Angela glen
Maria Angels Cubillo de Dios
Kevin Merchant
Ajay Kumar Mandal
Application Number:
JP2008518951A
Publication Date:
December 04, 2008
Filing Date:
June 27, 2006
Export Citation:
Assignee:
Takeda Cambridge Limited
International Classes:
C07D413/14; A61K31/506; A61K31/5377; A61K31/551; A61P3/10; A61P5/24; A61P13/08; A61P15/00; A61P15/16; A61P19/02; A61P25/00; A61P25/28; A61P31/18; A61P35/00; C07D403/12; C07D413/12; C07D417/12; C07D417/14
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro