Title:
HETEROCYCLIC RING-CONTAINING TRICYCLIC SULFONAMIDE AND SULFONIC ACID ESTER DERIVATIVE
Document Type and Number:
Japanese Patent JPH0881441
Kind Code:
A
Abstract:
PURPOSE: To obtain a heterocyclic ring-containing tricyclic sulfonamide which is represented by a specific formula and has an excellent antitumor activity with low toxicity.
CONSTITUTION: The compound of formula I {G is an aromatic 5- or 6-membered ring which may be mono- or disubstituted; L is-N(R1)-(R1 is H, a lower alkyl), O; M is a tricyclic structure of formula II-formula V [ring A and ring B are (substituted) unsaturated 5- or 6-membered ring; X is-N(R2)- (R2 is H, a lower alkyl), -NHCO-; Y is O,-S(O)n- (n is 0, 1, 2)] }, for example, 4-methoxy-N-(10H- phenothiazin-1-yl)benzenesulfonamide. It is preferred that this compound is obtained by reaction of a sulfonic acid (or its reactive derivative) of Gb-SO3H (Gb is G which may be protected) with H-L-Ma (M a is M which may be protected), when desired, followed by deprotection of the product.
Inventors:
YOSHINO HIROSHI
UEDA NORIHIRO
NIIJIMA ATSUSHI
HANEDA TORU
KOTAKE YOSHIHIKO
YOSHIMATSU KENTARO
WATANABE TATSUO
NAGASU TAKESHI
TSUKAHARA NAOKO
KOYANAGI NOZOMI
KITO KYOSUKE
Application Number:
JP17464394A
Publication Date:
March 26, 1996
Filing Date:
July 26, 1994
International Classes:
C07D243/38; A61K31/395; A61K31/40; A61K31/403; A61K31/435; A61K31/47; A61K31/473; A61K31/495; A61K31/498; A61K31/535; A61K31/536; A61K31/538; A61K31/54; A61K31/5415; A61K31/542; A61K31/55; A61K31/553; A61K31/554; A61P35/00; C07D209/88; C07D219/08; C07D221/12; C07D223/26; C07D223/28; C07D241/46; C07D265/38; C07D267/18; C07D267/20; C07D279/18; C07D279/20; C07D279/22; C07D281/14; C07D285/20; C07D285/36; C07D285/38; C07D498/04; C07D513/04; (IPC1-7): C07D209/88; A61K31/395; A61K31/495; C07D219/08; C07D221/12; C07D223/26; C07D223/28; C07D241/46; C07D243/38; C07D265/38; C07D267/18; C07D267/20; C07D279/18; C07D279/20; C07D279/22; C07D281/14; C07D285/20; C07D285/36; C07D285/38; C07D498/04; C07D513/04
