Title:
HETEROCYCLIC RING-CONTAINING TRICYCLIC SULFONAMIDE AND SULFONIC ACID ESTER DERIVATIVE
Document Type and Number:
Japanese Patent JP3690825
Kind Code:
B2
Abstract:
PURPOSE: To obtain a heterocyclic ring-containing tricyclic sulfonamide which is represented by a specific formula and has an excellent antitumor activity with low toxicity.
CONSTITUTION: The compound of formula I {G is an aromatic 5- or 6-membered ring which may be mono- or disubstituted; L is-N(R1)-(R1 is H, a lower alkyl), O; M is a tricyclic structure of formula II-formula V [ring A and ring B are (substituted) unsaturated 5- or 6-membered ring; X is-N(R2)- (R2 is H, a lower alkyl), -NHCO-; Y is O,-S(O)n- (n is 0, 1, 2)] }, for example, 4-methoxy-N-(10H- phenothiazin-1-yl)benzenesulfonamide. It is preferred that this compound is obtained by reaction of a sulfonic acid (or its reactive derivative) of Gb-SO3H (Gb is G which may be protected) with H-L-Ma (M a is M which may be protected), when desired, followed by deprotection of the product.
Inventors:
Hiroshi Yoshino
Ueda Norihiro
Niijima Jun
Haneda
Yoshihiko Kotake
Kentaro Yoshimatsu
Tatsuo Watanabe
Takeshi Nagasu
Naoko Tsukahara
Nozomi Koyanagi
Kyosuke Kito
Ueda Norihiro
Niijima Jun
Haneda
Yoshihiko Kotake
Kentaro Yoshimatsu
Tatsuo Watanabe
Takeshi Nagasu
Naoko Tsukahara
Nozomi Koyanagi
Kyosuke Kito
Application Number:
JP17464394A
Publication Date:
August 31, 2005
Filing Date:
July 26, 1994
Export Citation:
Assignee:
EISAI CO.,LTD.
International Classes:
C07D243/38; A61K31/395; A61K31/40; A61K31/403; A61K31/435; A61K31/47; A61K31/473; A61K31/495; A61K31/498; A61K31/535; A61K31/536; A61K31/538; A61K31/54; A61K31/5415; A61K31/542; A61K31/55; A61K31/553; A61K31/554; A61P35/00; C07D209/88; C07D219/08; C07D221/12; C07D223/26; C07D223/28; C07D241/46; C07D265/38; C07D267/18; C07D267/20; C07D279/18; C07D279/20; C07D279/22; C07D281/14; C07D285/20; C07D285/36; C07D285/38; C07D498/04; C07D513/04; (IPC1-7): C07D209/88; A61K31/403; A61K31/473; A61K31/498; A61K31/536; A61K31/5415; A61K31/542; A61K31/55; A61K31/553; A61K31/554; A61P35/00; C07D219/08; C07D221/12; C07D223/26; C07D241/46; C07D243/38; C07D265/38; C07D267/18; C07D267/20; C07D279/18; C07D279/20; C07D279/22; C07D281/14; C07D498/04; C07D513/04
Domestic Patent References:
| JP38025682B1 | ||||
| JP2196777A | ||||
| JP5039256A |
Other References:
Endo, Hideo,Antitumor activity of phenazine derivatives against S 180 and C63 [tumors] in mice. II,Science Reports of the Research Institutes, Tohoku University, Series C: Medicine,1966年,Vol.13, No.1-2,pp.12-14
Clarke, Simon J.,Competing [4 + 2] and [3 + 2] cycloaddition in the reactions of nucleophilic olefins with ethyl 3-(t,Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry,1983年,No.8,pp.1803-1807
Matsumura, Eizo,Chem. Abstr.,1962年,Vol.56,No.1-2,抄録番号第56:469h-i
Koksharova, T. G.,Acylation of 1-oxo-4-hydroxypyridazino[4,5-6]quinoxaline,Khimiya Geterotsiklicheskikh Soedinenii,1977年,No.3,pp.407-410
白井秀明,1-amino-10-propylphenoxazineの合成,名古屋市立大学薬学部研究年報第18号,1970年,pp.77-78
白井秀明,Phenoxazine 関連化合物の研究(第1報)1,2-dihydro-3H-pyrazino[3,2,1-kl]phenoxazineの合成,薬学雑誌,1970年,Vol.90, No.2,pp.214-18
Shirai, Hideaki,Syntheses of heterocyclic sulfur compounds. II. Syntheses of 3-tosyl-1,2-dihydro-3H-pyrazino[3,2,1,Chemical & Pharmaceutical Bulletin,1971年,Vol.19, No.5,pp.892-895
Samolovova, V. G.,Chem. Abstr.,1961年,Vol.55,No.23-24,抄録番号第55:23540f-i
Clarke, Simon J.,Competing [4 + 2] and [3 + 2] cycloaddition in the reactions of nucleophilic olefins with ethyl 3-(t,Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry,1983年,No.8,pp.1803-1807
Matsumura, Eizo,Chem. Abstr.,1962年,Vol.56,No.1-2,抄録番号第56:469h-i
Koksharova, T. G.,Acylation of 1-oxo-4-hydroxypyridazino[4,5-6]quinoxaline,Khimiya Geterotsiklicheskikh Soedinenii,1977年,No.3,pp.407-410
白井秀明,1-amino-10-propylphenoxazineの合成,名古屋市立大学薬学部研究年報第18号,1970年,pp.77-78
白井秀明,Phenoxazine 関連化合物の研究(第1報)1,2-dihydro-3H-pyrazino[3,2,1-kl]phenoxazineの合成,薬学雑誌,1970年,Vol.90, No.2,pp.214-18
Shirai, Hideaki,Syntheses of heterocyclic sulfur compounds. II. Syntheses of 3-tosyl-1,2-dihydro-3H-pyrazino[3,2,1,Chemical & Pharmaceutical Bulletin,1971年,Vol.19, No.5,pp.892-895
Samolovova, V. G.,Chem. Abstr.,1961年,Vol.55,No.23-24,抄録番号第55:23540f-i
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