低酸素選択的タンパク質キナーゼ阻害剤としての複素環トリアジン

Title:

低酸素選択的タンパク質キナーゼ阻害剤としての複素環トリアジン

Document Type and Number:

Japanese Patent JP2008528679

Kind Code:

A

Abstract:

The invention relates to novel heterocyclic N-oxides which are useful as hypoxic selective cytotoxic agents that mediate and/or inhibit cell proliferation, for example, through the activity of protein kinases. The invention is further related to pharmaceutical compositions containing such compounds and compositions, and to methods of treating cancer as well as other disease states associated with unwanted ahgiogenesis and/or cellular proliferation by administering effective amounts of such compounds.

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Inventors:

Bob, Boyle
Stuart, traverse

Application Number:

JP2007553748A

Publication Date:

July 31, 2008

Filing Date:

February 01, 2006

Export Citation:

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Assignee:

SENTINEL ONCOLOGY LIMITED

International Classes:

A61K31/53; A61K45/00; A61P9/00; A61P35/00; A61P43/00; C07D215/48; C07D215/60; C07D239/94; C07D241/20; C07D241/54; C07D253/08; C07D401/04; C07D401/12; C07D401/14; C07D471/04; C07D487/04

Attorney, Agent or Firm:

Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Omori Miko

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