Title:
HETERODIMERIC ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS
Document Type and Number:
Japanese Patent JP2023113868
Kind Code:
A
Abstract:
To provide novel heterodimeric antibodies.SOLUTION: A heterodimeric antibody with specific sequences comprises: a) a first monomer comprising i) a first heavy chain comprising 1) a first variable heavy domain, 2) a first constant heavy chain comprising a first Fc domain, and 3) an scFv comprising an scFv variable light domain, an scFv linker and an scFv variable heavy domain, where the scFv is covalently attached to the C-terminus of the Fc domain using a domain linker; b) a second monomer comprising a second heavy chain comprising a second variable heavy domain and a second constant heavy chain comprising a second Fc domain; and c) a common light chain comprising a variable light domain and a constant light domain.SELECTED DRAWING: None
Inventors:
GREGORY L MOORE
JOHN DESLARLAIS
MATTHEW BERNETT
CHU SEUNG
RUMANA RASHID
UMESH MUCHHAL
LEE SUNG-HYUNG
JOHN DESLARLAIS
MATTHEW BERNETT
CHU SEUNG
RUMANA RASHID
UMESH MUCHHAL
LEE SUNG-HYUNG
Application Number:
JP2023094234A
Publication Date:
August 16, 2023
Filing Date:
June 07, 2023
Export Citation:
Assignee:
XENCOR INC
International Classes:
C12N15/13; A61K39/395; A61K47/68; A61P35/00; A61P35/02; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12N15/63; C12P21/08
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Noriki Mihashi
Norio Omori
Noriki Mihashi
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