HEXAHYDROO2*66METHANOO33BENZOAZOSINE AND ITS MANUFACTURE

Title:

HEXAHYDROO2*66METHANOO33BENZOAZOSINE AND ITS MANUFACTURE

Document Type and Number:

Japanese Patent JPS5585569

Kind Code:

A

Abstract:

3-R1-7-R2''-8-R2-9-R2'-10-R2'''-11(ax)-R3-6(eq)-R4-11(eq)-(CH2CH2CH2R5 )-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, generally useful as morphine-like analgesics and as narcotic antagonists, are prepared by reducing, under Wolff-Kishner reaction conditions, a corresponding 3-R1-7-R2''-8-R2-9-R2'-10-R2'''-11(ax)-R3-6(eq)-R4-11(eq)-(CH2CH2COR5) -1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and, if desired, cleaving a lower-alkoxy, methoxymethoxy or benzyloxy group to an hydroxy group.

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Inventors:

UIRIAMU FURANSHISU MAIKUN
TOOMASU RICHIYAADO RUISU

Application Number:

JP15549379A

Publication Date:

June 27, 1980

Filing Date:

November 30, 1979

Export Citation:

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Assignee:

STERLING DRUG INC

International Classes:

A61K31/435; A61K31/47; A61P25/04; A61P25/30; C07D221/26; (IPC1-7): A61K31/435; A61K31/47; C07D221/26

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