Title:
HIGH AFFINITY BINDING SITE OF HGFR AND METHOD FOR IDENTIFYING ANTAGONIST THEREOF
Document Type and Number:
Japanese Patent JP2009291191
Kind Code:
A
Abstract:
To provide a means for enabling identification of a hepatocyte growth factor receptor (HGFR) antagonist accompanied by increase of sensitivity and reduction of adverse effects to develop therapeutic strategy effective for cancer therapy.
The activity, function, stability and/or expression of the HGFR can be measured by bringing a test agent to contact with (i) a polynucleotide encoding extracellular IPT-3 and IPT-4 domains of the HGFR, (ii) a polypeptide containing the domain or (iii) a cell expressing extracellular IPT-3 and IPT-4 domains of the HGFR.
Inventors:
COMOGLIO PAOLO MARIA
CARMINATI PAOLO
MICHIELI PAOLO
BASILICO CRISTINA
CARMINATI PAOLO
MICHIELI PAOLO
BASILICO CRISTINA
Application Number:
JP2009117725A
Publication Date:
December 17, 2009
Filing Date:
May 14, 2009
Export Citation:
Assignee:
METHERESIS TRANSLATIONAL RES S
International Classes:
C12Q1/02; C12N15/09; C12Q1/48; C12Q1/68; C07K14/71
Domestic Patent References:
| JPH11506327A | 1999-06-08 | |||
| JPH11506327A | 1999-06-08 |
Foreign References:
| WO2007013603A1 | 2007-02-01 | |||
| US20060008844A1 | 2006-01-12 | |||
| WO2007013603A1 | 2007-02-01 | |||
| US20060008844A1 | 2006-01-12 |
Other References:
JPN6013058584; Ｋｏｎｇ-Ｂｅｌｔｒａｎ ｅｔ ａｌ: ＣＡＮＣＥＲ ＣＥＬＬ ＶＯＬ． ６, 200407, ｐ． ７５-８４
JPN6013058585; Ｗａｎｇ ｅｔ ａｌ: Ｍｏｌｅｃｕｌａｒ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ , 2003, ｐ． １０８５-１０９２
JPN6013058586; Ｂａｓｉｌｉｃｏ ｅｔ ａｌ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＶＯＬ． ２８３， ＮＯ． ３０, 20080725, ｐ． ２１２６７-２１２７７
JPN6013058583; Ｍｉｃｈｉｅｌｉ ｅｔ ａｌ: ＣＡＮＣＥＲ ＣＥＬＬ ＶＯＬ． ６, 200407, ｐ． ６１-７３
JPN6013058584; Ｋｏｎｇ-Ｂｅｌｔｒａｎ ｅｔ ａｌ: ＣＡＮＣＥＲ ＣＥＬＬ ＶＯＬ． ６, 200407, ｐ． ７５-８４
JPN6013058585; Ｗａｎｇ ｅｔ ａｌ: Ｍｏｌｅｃｕｌａｒ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ , 2003, ｐ． １０８５-１０９２
JPN6013058586; Ｂａｓｉｌｉｃｏ ｅｔ ａｌ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＶＯＬ． ２８３， ＮＯ． ３０, 20080725, ｐ． ２１２６７-２１２７７
JPN6013058585; Ｗａｎｇ ｅｔ ａｌ: Ｍｏｌｅｃｕｌａｒ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ , 2003, ｐ． １０８５-１０９２
JPN6013058586; Ｂａｓｉｌｉｃｏ ｅｔ ａｌ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＶＯＬ． ２８３， ＮＯ． ３０, 20080725, ｐ． ２１２６７-２１２７７
JPN6013058583; Ｍｉｃｈｉｅｌｉ ｅｔ ａｌ: ＣＡＮＣＥＲ ＣＥＬＬ ＶＯＬ． ６, 200407, ｐ． ６１-７３
JPN6013058584; Ｋｏｎｇ-Ｂｅｌｔｒａｎ ｅｔ ａｌ: ＣＡＮＣＥＲ ＣＥＬＬ ＶＯＬ． ６, 200407, ｐ． ７５-８４
JPN6013058585; Ｗａｎｇ ｅｔ ａｌ: Ｍｏｌｅｃｕｌａｒ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ , 2003, ｐ． １０８５-１０９２
JPN6013058586; Ｂａｓｉｌｉｃｏ ｅｔ ａｌ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ＶＯＬ． ２８３， ＮＯ． ３０, 20080725, ｐ． ２１２６７-２１２７７
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Nishino Mitsuru
Fumio Inai
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Nishino Mitsuru
Fumio Inai