Title:
高純度リポペプチド、リポペプチドミセルおよびこれらを調製するための処理
Document Type and Number:
Japanese Patent JP5303087
Kind Code:
B2
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of Streptomyces roseosporus. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
Inventors:
Kelher, Thomas Jay.
Rye, Jean-Ji
Dekosey, Joseph P.
Lynch, Paul Dee.
Celoni, Maurizio
Taryani, Auro Ele.
Rye, Jean-Ji
Dekosey, Joseph P.
Lynch, Paul Dee.
Celoni, Maurizio
Taryani, Auro Ele.
Application Number:
JP2001553802A
Publication Date:
October 02, 2013
Filing Date:
January 18, 2001
Export Citation:
Assignee:
Cubist Pharmaceuticals, Incorporated
International Classes:
C07K7/08; A61K38/00; C12P21/02; A61K38/08; A61K38/10; A61K38/12; A61K45/00; A61K45/06; A61P29/00; A61P31/04; A61P31/10; C07K1/18; C07K1/20; C07K1/34; C07K1/36; C07K5/097; C07K7/00; C12P17/16; C12R1/465; C07K
Domestic Patent References:
| JP7097394A | ||||
| JP61092588A | ||||
| JP64047388A |
Foreign References:
| WO1999040113A1 | ||||
| US5912226 |
Other References:
Expert Opin. Investig. Drugs (1999) vol.8, no.8, p.1223-1238
J. Chromatogr. A (1998) vol.825, no.2, p.149-159
Biotechnology Techniques (1997) vol.11, no.6, p.413-416
J. Antibiot. (1988) vol.41, no.8, p.1093-1105
J. Chromatogr. A (1998) vol.825, no.2, p.149-159
Biotechnology Techniques (1997) vol.11, no.6, p.413-416
J. Antibiot. (1988) vol.41, no.8, p.1093-1105
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama