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Title:
HIGH TITER RECOMBINANT INFLUENZA VIRUSES FOR VACCINES
Document Type and Number:
Japanese Patent JP2014131516
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide high titer recombinant influenza viruses for vaccines.SOLUTION: The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes at least five internal genes from an influenza virus isolate that replicates to high titers in embryonated chicken eggs or MDCK cells.

Inventors:
KAWAOKA YOSHIHIRO
HORIMOTO TAISUKE
MURAKAMI SUSUMU
Application Number:
JP2014049025A
Publication Date:
July 17, 2014
Filing Date:
March 12, 2014
Export Citation:
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Assignee:
WARF WISCONSIN ALUMNI RES FOUNDATION
International Classes:
C12N15/09; A61K39/145; C12N7/04; A61K39/00
Domestic Patent References:
JP2005245302A2005-09-15
JP2005535288A2005-11-24
JP2004500842A2004-01-15
JP2005523698A2005-08-11
Foreign References:
WO2004112831A22004-12-29
WO2005062820A22005-07-14
Other References:
JPN6012054310; Proceedings of the National Academy of Sciences Vol.97, No.11, 2000, pp.6108-6113
JPN6012054313; Reviews in Medical Virology Vol.12, 2002, pp.13-30
JPN6012054315; Vaccine Vol.22, 2004, pp.3175-3181
JPN6015023896; WINTER G. et al.: Nucleic Acids Res. Vol.9, No.2, 1981, pp.237-245
JPN6015023897; BAEZ M. et al.: Nucleic Acids Res. Vol.23, No.8, 1980, pp.5845-5858
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei