高形質導入効率ｒＡＡＶベクター、組成物、および使用方法

Japanese Patent JP6563334

B2

The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.

JP7423682	Adeno-associated virus virion with mutant capsid and method for using the same
JP2022525955	Recombinant adeno-associated virus vector
JP7330899	Methods and compositions for altering viral assembly-activating protein (AAP) dependence

Arun Srivastaba
George Vladimirovich Aslanidi
Kim M Bang Burito
Mavis Agvanje-McKenna

JP2015512808A

August 21, 2019

May 15, 2013

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University of Florida Research Foundation Incorporated

C12N15/35; A61K35/76; A61K47/42; A61K48/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/02; A61P19/08; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P35/00; A61P37/06; C07K14/015; C12N5/10; C12N7/00; C12N15/864

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PROTEINS, 2010年,Vol.78,p.365-380

Michiko Matsutani
Kenji Tomita
Fumio Inai
Manami Sasakura

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