Title:
哺乳動物の外科的若しくは治療的な処置方法、又は診断方法に使用、特に血漿増量剤に使用をする高度分枝アミロペクチン
Document Type and Number:
Japanese Patent JP2005501930
Kind Code:
A
Abstract:
The invention relates to the use of hyperbranched amylopectin which has an average branch degree of between >10 and 25 mol % and a molecular weight (Mw) ranging from 40.000-800.000 Dalton and the derivatives thereof in methods for surgical or therapeutic treatment of human or animal bodies or in a diagnostic method, preferably as a plasma volume expander. Plasma volume expanders based on hydroxy-ethylated amylopectin have, as a result of hydroxy ethylation, hitherto exhibited the disadvantage of incomplete metabolism and thus temporary tissue storage which is linked to side-effects. According to the invention, novel plasma expanders based on polysaccharides which do not exhibit the same disadvantages as the former are provided. Improved, completely metabolised plasma expanders based on hyperbranched amylopectin which can be obtained therefrom so that native plant-amylopectins are altered-by transglycosylation in such a way the adjustable, high degree of branching enables control of the serum-alpha-amylase decomposition so that no or only a very insignificant degree of hydroxy ethylation is necessary.
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Inventors:
Sommermeier Claus
Application Number:
JP2003523498A
Publication Date:
January 20, 2005
Filing Date:
August 06, 2002
Export Citation:
Assignee:
Spiramor Parental Co-Royce GMBH
International Classes:
A01N1/02; A61K9/00; A61K31/718; A61K47/36; A61P7/08; A61P9/00; C08B30/20; C08B35/00; (IPC1-7): C08B30/20; A61K31/718; A61P7/08; A61P9/00
Attorney, Agent or Firm:
Eisuke Fujimoto