Title:
HIGHLY CONCENTRATED DRUG PARTICLES, FORMULATIONS, SUSPENSIONS AND USES THEREOF
Document Type and Number:
Japanese Patent JP2015017143
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide novel highly concentrated drug particle formulations.SOLUTION: The drug comprises between about 25 wt.% and 80 wt.% of the particle formulation. The particle formulations of the present invention comprise, for example, macromolecules, such as proteins and/or small molecules (such as steroid hormones). The particle formulation typically further includes one or more additional component, for example, one or more stabilizer (e.g., carbohydrates, antioxidants, amino acids, and buffers). Such highly concentrated particle formulations can be combined with a suspension vehicle to form suspension formulations. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymers and one or more solvents, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a highly concentrated drug particle formulation. Devices for delivering the suspension formulations and methods of use are also described. The present invention provides needed improvement means in drug formulation and delivery to improve patient compliance and expand drug availability.
Inventors:
ALESSI THOMAS R
RYAN D MERCER
CATHERINE M ROHLOFF
BING YANG
RYAN D MERCER
CATHERINE M ROHLOFF
BING YANG
Application Number:
JP2014221571A
Publication Date:
January 29, 2015
Filing Date:
October 30, 2014
Export Citation:
Assignee:
INTARCIA THERAPEUTICS INC
International Classes:
A61K9/10; A61K9/14; A61K38/00; A61K38/21; A61K38/26; A61K38/27; A61K39/395; A61K47/12; A61K47/18; A61K47/20; A61K47/26
Domestic Patent References:
| JP2008528698A | 2008-07-31 | |||
| JP2008509160A | 2008-03-27 |
Foreign References:
| WO2008021133A2 | 2008-02-21 | |||
| US20060193918A1 | 2006-08-31 | |||
| WO2008133908A2 | 2008-11-06 |
Other References:
J. DIABETES SCI. TECHNOL., vol. 461, JPN6016006015, May 2008 (2008-05-01), pages 461 - 467, ISSN: 0003406580
REV. DIABET. STUD., vol. 5, no. 2, JPN6016037202, August 2008 (2008-08-01), pages 73 - 94, ISSN: 0003406581
REV. DIABET. STUD., vol. 5, no. 2, JPN6016037202, August 2008 (2008-08-01), pages 73 - 94, ISSN: 0003406581
Attorney, Agent or Firm:
Aoki 篤
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Yoichi Watanabe
Nakajima 勝
Ikeda Tatsunori
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Yoichi Watanabe
Nakajima 勝
Ikeda Tatsunori