Title:
核多形性の組織学的評価
Document Type and Number:
Japanese Patent JP4383352
Kind Code:
B2
Abstract:
A method of histological assessment of nuclear pleomorphism to identify potential cell nuclei divides image data into overlapping sub-images. It uses principal component analysis to derive monochromatic image data, followed by Otsu thresholding to produce a binary image. It removes image regions at sub-image boundaries, unsuitably small image regions and holes in relatively large image regions. It then reassembles the resulting sub-images into a single image. Perimeters (P) and areas (A) of image regions which are potential cell nuclei are determined and used in calculating nuclear shape factors P2/A. Nuclear pleomorphism is assessed as relatively low, moderate or high according to whether predetermined shape factor thresholds indicate a mean cell nucleus shape factor for an image is relatively low, moderate or high.
Inventors:
Maria petro
Anthasia
Burger, margaret jay
Ducksbury, Paul Theraard
Anthasia
Burger, margaret jay
Ducksbury, Paul Theraard
Application Number:
JP2004552851A
Publication Date:
December 16, 2009
Filing Date:
November 13, 2003
Export Citation:
Assignee:
Kinetic Limited
International Classes:
G06T1/00; G06T7/00; G06T7/60
Domestic Patent References:
| JP6231229A |
Other References:
村瀬曜子 田中敏幸 岡輝明,画像処理による皮膚腫瘍の分類の検討,電気学会論文誌C Vol.122-C No.10,日本,(社)電気学会,2002年10月 1日,第122-C巻
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Makoto Ono
Katsuma Osaki