Title:
ヒストンデアセチラーゼ阻害剤
Document Type and Number:
Japanese Patent JP2010523601
Kind Code:
A
Abstract:
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
Inventors:
Tessier, Pierre
Late, Silvana
Smil, David
Dejielle, robert
Ajamian, Alan
Chantilly, Eve, Andre
Dominguez, Ceria
Late, Silvana
Smil, David
Dejielle, robert
Ajamian, Alan
Chantilly, Eve, Andre
Dominguez, Ceria
Application Number:
JP2010502392A
Publication Date:
July 15, 2010
Filing Date:
April 09, 2008
Export Citation:
Assignee:
Mesilegene Incorporated
International Classes:
C07C259/06; A61K31/16; A61K31/165; A61K31/18; A61K31/343; A61K31/352; A61K31/36; A61K31/381; A61K31/397; A61K31/40; A61K31/403; A61K31/405; A61K31/407; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/426; A61K31/437; A61K31/438; A61K31/4406; A61K31/443; A61K31/4439; A61K31/445; A61K31/4453; A61K31/454; A61K31/4545; A61K31/47; A61K31/473; A61K31/495; A61K31/505; A61K31/506; A61K31/5375; A61K31/538; A61K31/54; A61K45/00; A61P3/10; A61P9/00; A61P25/08; A61P25/24; A61P29/00; A61P31/10; A61P31/12; A61P35/00; A61P37/00; C07C259/08; C07C311/19; C07C317/44; C07C323/20; C07C323/62; C07D207/09; C07D207/337; C07D209/08; C07D209/44; C07D209/94; C07D211/14; C07D211/34; C07D211/44; C07D213/56; C07D215/24; C07D219/04; C07D233/42; C07D235/16; C07D239/26; C07D239/38; C07D239/42; C07D249/04; C07D277/74; C07D279/12; C07D285/12; C07D295/08; C07D295/22; C07D307/81; C07D311/84; C07D319/16; C07D333/24; C07D401/04; C07D401/06; C07D409/04; C07D413/04; C07D413/14; C07D417/04; C07D471/04; C07D491/113; C07D493/08; C07D513/04
Domestic Patent References:
JPH05186431A | 1993-07-27 | |||
JP2003514904A | 2003-04-22 | |||
JP2004509105A | 2004-03-25 | |||
JPH05186431A | 1993-07-27 | |||
JP2003514904A | 2003-04-22 | |||
JP2004509105A | 2004-03-25 |
Other References:
JPN6013032112; Buraczewski, Krzysztof; Czerwinska, Elzbieta; Eckstein, Zygmunt; Grochowski, Edward; Kowalik, Ro: 'The properties and fungicidal activity of some aryl derivatives of hydroxamic acid' Przemysl Chemiczny 43(11), 1964, 626-9
JPN6013032110; Eckstein, Zygmunt; Rusek, Dorota: 'Possible synthesis and use of diarylacetohydroximic chlorides' Przemysl Chemiczny 58(5), 1979, 235-8
JPN6013032111; KrennHrubec, Keris; Marshall, Brett L.; Hedglin, Mark; Verdin, Eric; Ulrich, Scott M.: 'Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors' Bioorganic and Medicinal Chemistry Letters 17(10), 2007, 2874-2878
JPN6013032110; Eckstein, Zygmunt; Rusek, Dorota: 'Possible synthesis and use of diarylacetohydroximic chlorides' Przemysl Chemiczny 58(5), 1979, 235-8
JPN6013032111; KrennHrubec, Keris; Marshall, Brett L.; Hedglin, Mark; Verdin, Eric; Ulrich, Scott M.: 'Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors' Bioorganic and Medicinal Chemistry Letters 17(10), 2007, 2874-2878
JPN6013032112; Buraczewski, Krzysztof; Czerwinska, Elzbieta; Eckstein, Zygmunt; Grochowski, Edward; Kowalik, Ro: 'The properties and fungicidal activity of some aryl derivatives of hydroxamic acid' Przemysl Chemiczny 43(11), 1964, 626-9
JPN6013032110; Eckstein, Zygmunt; Rusek, Dorota: 'Possible synthesis and use of diarylacetohydroximic chlorides' Przemysl Chemiczny 58(5), 1979, 235-8
JPN6013032111; KrennHrubec, Keris; Marshall, Brett L.; Hedglin, Mark; Verdin, Eric; Ulrich, Scott M.: 'Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors' Bioorganic and Medicinal Chemistry Letters 17(10), 2007, 2874-2878
JPN6013032110; Eckstein, Zygmunt; Rusek, Dorota: 'Possible synthesis and use of diarylacetohydroximic chlorides' Przemysl Chemiczny 58(5), 1979, 235-8
JPN6013032111; KrennHrubec, Keris; Marshall, Brett L.; Hedglin, Mark; Verdin, Eric; Ulrich, Scott M.: 'Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors' Bioorganic and Medicinal Chemistry Letters 17(10), 2007, 2874-2878
JPN6013032112; Buraczewski, Krzysztof; Czerwinska, Elzbieta; Eckstein, Zygmunt; Grochowski, Edward; Kowalik, Ro: 'The properties and fungicidal activity of some aryl derivatives of hydroxamic acid' Przemysl Chemiczny 43(11), 1964, 626-9
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Mari Yuge
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Yoshitaka Watanabe
Hideto Asamura
Hajime Asamura
Mari Yuge
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Yoshitaka Watanabe