Title:
臓器障害を示すマーカーとしてのヒストンおよび／またはｐｒｏＡＤＭ
Document Type and Number:
Japanese Patent JP7194673
Kind Code:
B2
Abstract:
The present invention relates to the diagnosis, prognosis, risk assessment, risk stratification, monitoring, therapy guidance and/or therapy control of organ dysfunction in a subject. The invention relates to a method that comprises determining a level of at least one histone, particularly H2B, H4, H2A and/or H3, in a sample of said subject and wherein said level of at least one histone is indicative of said organ dysfunction. Further, the invention relates to a method that comprises determining a level of proadrenomedullin (proADM), particularly midregional proadrenomedullin (MR-proADM), in a sample of said subject and wherein said level of proADM is indicative of said organ dysfunction. The invention further relates to kits for carrying out the methods of the invention.
Inventors:
Zira Tim
Dreyer Frauke
Ancamp Anne
Crop Manne
Charles Pierre Emmanuel
Dreyer Frauke
Ancamp Anne
Crop Manne
Charles Pierre Emmanuel
Application Number:
JP2019507120A
Publication Date:
December 22, 2022
Filing Date:
August 08, 2017
Export Citation:
Assignee:
B. L. A. Har. M. S. Gezel Shaft Mitt Beschlenktel Haftung
International Classes:
G01N33/68
Foreign References:
| US20100035275 | ||||
| WO2016128383A1 |
Other References:
Circulating Histones: A Novel Target in Acute Respiratory Distress Syndrome?,American Journal of Respiratory and Critical Care Medicine,2013年,Vol.187, No.2,pp.118-120
Matthew E Kutcher et al.,Extracellular Histone Release in Response to Traumatic Injury: Implications for a Compensatory Role of Activated Protein C,Journal of Trauma and Acute Care Surgery,2012年12月,Vol.73, Vol.6,pp.1-14
Ferruh Artunc et al.,Plasma Concentrations of the Vasoactive Peptide Fragments Mid-regional Pro-Adrenomedullin, C-Terminatl Pro-Endothelin 1 and Copeptin in Hemodualysis Patients: Associated Factors and Prediction of Mortality,PLOS ONE,2014年01月,Vol.9, No.1,e86148
Matthew E Kutcher et al.,Extracellular Histone Release in Response to Traumatic Injury: Implications for a Compensatory Role of Activated Protein C,Journal of Trauma and Acute Care Surgery,2012年12月,Vol.73, Vol.6,pp.1-14
Ferruh Artunc et al.,Plasma Concentrations of the Vasoactive Peptide Fragments Mid-regional Pro-Adrenomedullin, C-Terminatl Pro-Endothelin 1 and Copeptin in Hemodualysis Patients: Associated Factors and Prediction of Mortality,PLOS ONE,2014年01月,Vol.9, No.1,e86148
Attorney, Agent or Firm:
Sykes Patent Attorney Corporation