PURPOSE: To obtain the subject new compound useful for preventing and treating human immunodeficiency viral infection and treating AIDS.
CONSTITUTION: The objective compound of formula I {R0 is H or a 2-6C alkanoyl; (n) is 0 or 2; R is an aryl, a heterocycle or the like; R1 is an aryl, a 5-7C cycloalkyl or the like; R2 is an amino acid side chain, CH2SCH3 or the like; X is formulae II, III [Y is an aryl or an unsaturated heterocycle; Y1 is a heterocycle; R3a is C(O)-NR4R4, formula IV (R4 is H, a 1-6C alkyl or the like; R5, R6 are each H, amino or the like) or the like] or the like}, e.g. [2R-(2 R*,3S*,6S*,9S*)]-N-t-butyl-2-[2-hydrxoy-3-phenylmethyl-4,7-diaza-5,8-dioxo-6-(1- methylethyl)-9N-(t-butoxycarbonyl)amino-10-naphthalen-1-yl]decylbenzaldehyde, is obtained by reacting a compound of formula V with a compound of formula VI (Rb is a protective group for amino group), then eliminating the protective group, and reacting the resultant compound with a compound of formula VII.
CHIYAARUZU DEIBITSUDO JIYOONZU
RUISU NIKORASU JIYUNGAIMU
PAMERA AN PENINTON
