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Title:
目的タンパク質を産生するための宿主細胞
Document Type and Number:
Japanese Patent JP2021513370
Kind Code:
A
Abstract:
異種目的タンパク質（ＰＯＩ）を産生するように設計された真核宿主細胞であって、３つの異なる内因性の宿主細胞タンパク質（ＨＣＰ）のうちの少なくとも１つの産生を低減するように遺伝子改変された真核宿主細胞及びＰＯＩを産生する方法におけるその使用。

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Inventors:
Klaes, Catrien
Graham, James
Josbiac, Silvia
Kiziak, Christoph
Application Number:
JP2020565523A
Publication Date:
May 27, 2021
Filing Date:
January 30, 2019
Export Citation:
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Assignee:
LONZA LIMITED
International Classes:
C12N1/19; C12N1/15; C12N5/10; C12N15/12; C12N15/13; C12N15/16; C12N15/19; C12N15/52; C12N15/62; C12N15/79; C12P21/02; C12P21/08
Domestic Patent References:
JP2017511147A2017-04-20
JP2012510808A2012-05-17
JP2014530016A2014-11-17
Foreign References:
EP2258855A12010-12-08
CN102276704A2011-12-14
Other References:
"Lean-proteome strains - next step in metabolic engineering", FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 3, JPN6022035492, 2015, pages 1 - 3, ISSN: 0005022141
"Genetic basis of proteome variation in yeast", NATURE GENETICS, vol. 39, no. 11, JPN6022035493, 2007, pages 1369 - 1375, ISSN: 0005022142
Attorney, Agent or Firm:
Kurata Masatoshi
Nobuhisa Nogawa
Tadashi Inoue
Shigeru Iino
Oku Ikuharu
Naoki Kono
Sanae Kaneko



 
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