Title:
タウフィラメント形成重合を阻害するかまたは逆転させる方法
Document Type and Number:
Japanese Patent JP2005500346
Kind Code:
A
Abstract:
Methods for inhibiting and/or reversing tau filament formation or polymerization are provided. These methods can be used for treating certain neurological disorders in vivo by administering pharmaceutical compositions which inhibit and/or reverse tau filament formation or polymerization. An especially preferred pharmaceutical composition contains an inhibitor of the general formula (I), wherein R 1 is an aliphatic radical having one to six carbon atoms and wherein R 2 and R 3 independently are a second aliphatic radical having one to six carbon atoms, a hydroxyl-substituted aliphatic radical having one to six carbon atoms, or a pheny radical or a pharmaceutically acceptable salt of the inhibitor.
Inventors:
Jeff Clet
Sam Katami
Sam Katami
Application Number:
JP2003516520A
Publication Date:
January 06, 2005
Filing Date:
July 31, 2002
Export Citation:
Assignee:
Neuronautics, Inc.
International Classes:
C07D333/36; A61K31/00; A61K31/195; A61K31/38; A61K31/381; A61K31/40; A61K31/404; A61K31/425; A61K31/428; A61K31/655; A61P25/28; A61P43/00; C07D209/40; C07D277/64; C07D277/82; (IPC1-7): A61K31/381; A61K31/404; A61K31/428; A61K31/655; A61P25/28; A61P43/00
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe