カルバペネム抗生物質の合成方法

Title:

カルバペネム抗生物質の合成方法

Document Type and Number:

Japanese Patent JP3953274

Kind Code:

B2

Abstract:

A process for the direct crystallization of a compound of formula (I) or a pharmaceutically acceptable salt thereof, is disclosed, wherein R<1> and R<2> represent H, C1-10 alkyl, aryl or heteroaryl, or substituted C1-10 alkyl, aryl or heteroaryl and X<+> represents a charge balancing group, comprising extracting a solution containing a crude compound of formula (I) or (Ia) or a pharmaceutically acceptable salt thereof, wherein each X<+> is a charge balancing group, and R<1> and R<2> are as described above with a C4-10 alcohol, collecting and crystallizing the resulting aqueous phase to produce a crystalline compound of formula (I).

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Inventors:

Williams, Jiyoung M
Brands, Karel M Ye
Scari, Renato
Houghton, Peter

Application Number:

JP2000534552A

Publication Date:

August 08, 2007

Filing Date:

February 26, 1999

Export Citation:

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Assignee:

MERCK & COMPANY INCOPORATED

International Classes:

C07D477/00; A61K31/397; A61K31/407; A61P31/04; C07D477/02; C07D477/20

Domestic Patent References:

JP6506704A

Attorney, Agent or Firm:

Yoshio Kawaguchi
Naoya Fushimi
Makoto Ono
Natsuo Tanaka

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