Title:
PMSR相同体を使用する超変異性細胞の作成方法
Document Type and Number:
Japanese Patent JP2005531291
Kind Code:
A
Abstract:
Methods of making cells hypermutable are disclosed using PMS2 homologs that have a common sequence motif. The PMS2 homologs of the invention have ATPase-like motifs and are at least about 90% identical to PMS2-134. Methods of generating mutant libraries and using the PMS2 homologs in diagnostic and therapeutic applications for cancer are also disclosed.
Inventors:
Lutzji
Nicolaides, Nicholas Sea
Sass, Philip M
Nicolaides, Nicholas Sea
Sass, Philip M
Application Number:
JP2003571420A
Publication Date:
October 20, 2005
Filing Date:
February 21, 2003
Export Citation:
Assignee:
Morph Tech Incorporated
International Classes:
G01N33/53; A61K31/7105; A61K48/00; A61P35/00; C07K14/47; C12N1/21; C12N5/10; C12N15/09; C12N15/10; C12Q1/02; C12Q1/68; (IPC1-7): C12N15/09; A61K31/7105; A61K48/00; A61P35/00; C12N1/21; C12N5/10; C12Q1/02; C12Q1/68; G01N33/53
Foreign References:
| US6146894A | 2000-11-14 | |||
| WO2001059092A2 | 2001-08-16 | |||
| WO2001062945A1 | 2001-08-30 | |||
| WO2001088192A2 | 2001-11-22 |
Attorney, Agent or Firm:
Heikichi Odashima