Title:
血液腫瘍および血液癌を処置する方法
Document Type and Number:
Japanese Patent JP2004535363
Kind Code:
A
Abstract:
Multiple myeloma and other hematologic tumors and/or malignancies can be treated by administration of a G1 and/or S phase drug, which is preferably beta-lapachone, or a derivative or analog thereof, combined with a G2/M phase drug such as a taxane derivative, which is advantageously paclitaxel. This combination of the G1 and/or S phase drug with the G2/M phase drug results in an unexpectedly greater than additive (i.e., synergistic) apoptosis in multiple myeloma cells. The invention includes methods of treating multiple myeloma by administering the combination of the G1 and/or S phase drug and the G2/M phase drug, pharmaceutical compositions comprising the combination of drugs used in these methods, as well as pharmaceutical kits.
Inventors:
Pardy, Arthur Bee.
Anderson, Kenneth
Gupta, Deepak
Li, Chang
Ri, yozoo
Anderson, Kenneth
Gupta, Deepak
Li, Chang
Ri, yozoo
Application Number:
JP2002559028A
Publication Date:
November 25, 2004
Filing Date:
November 07, 2001
Export Citation:
Assignee:
Dana-Farber Cancer Institute, Incorporated
International Classes:
C07D311/92; A61K31/00; A61K31/337; A61K31/352; A61K31/4745; A61K31/704; A61K31/7048; A61K45/00; A61K45/06; A61K47/10; A61K47/32; A61K47/34; A61K47/40; A61P35/00; A61P35/02; (IPC1-7): A61K45/00; A61K31/352; A61K45/06; A61K47/10; A61K47/32; A61K47/34; A61K47/40; A61P35/00; A61P35/02
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita