Title:
男性不妊関連遺伝子プロタミン-2変異と男性不妊の診断方法
Document Type and Number:
Japanese Patent JP4276691
Kind Code:
B2
Abstract:
The present invention provides a group of mouse spermatogenesis genes, which is an assembly of 89 genes in total, wherein the respective genes transcribe mRNAs from which cDNAs having the respective base sequences of SEQ ID NOs:1 to 89 are synthesized; an Scot-t gene mutation and a protamine-2 gene mutation which are human homologues of genes belonging to the group of mouse genes and associated with human male infertility. The invention also provides a group of mouse spermatogenesis genes and various molecular biological materials relating thereto; various molecular biological materials relating to male infertility-associated gene mutations; and various test methods and diagnostic methods using the same.
Inventors:
Nishimune Yoshitake
Hiromitsu Tanaka
Masami Nozaki
Hiromitsu Tanaka
Masami Nozaki
Application Number:
JP2008016851A
Publication Date:
June 10, 2009
Filing Date:
January 28, 2008
Export Citation:
Assignee:
Hiromitsu Tanaka
International Classes:
C12N15/09; C07K14/47; C07K16/18; C12M1/00; C12N15/12; C12N15/52; C12Q1/68; G01N33/53; G01N33/536; G01N33/566
Other References:
Genomics,1990年,Vol.8,pp.127-133
Nature Genetics,2001年,Vol.28,pp.82-86
Human Reproduction,2001年,Vol.16, No.4,pp.709-716
Fertility and Sterility,2000年,Vol.73, No.6,pp.1104-1108
Mol. Hum. Reprod.,1998年,Vol.4, No.9,pp.827-834
Fertility and Sterility,1998年,Vol.69, No.4,pp.755-759
Experientia,1988年,Vol.44, No.1,pp.52-55
J. Biol. Chem.,1993年,Vol.268, No.14,pp.10553-10557
大海忍ほか著,細胞工学別冊 実験プロトコールシリーズ 抗ペプチド抗体実験プロトコール -ペプチド合成からタンパク質機能解析まで-,株式会社秀潤社,1994年 9月10日,pp.14-24
Mol. Reprod. Dev.,1993年,Vol.34, No.1,pp.53-57
Genet. Test,1997年,Vol.1, No.2,pp.125-129
Nucleic Acids Research,1990年,Vol.18, No.5,pp.1249-1254
Nature Genetics,2001年,Vol.28,pp.82-86
Human Reproduction,2001年,Vol.16, No.4,pp.709-716
Fertility and Sterility,2000年,Vol.73, No.6,pp.1104-1108
Mol. Hum. Reprod.,1998年,Vol.4, No.9,pp.827-834
Fertility and Sterility,1998年,Vol.69, No.4,pp.755-759
Experientia,1988年,Vol.44, No.1,pp.52-55
J. Biol. Chem.,1993年,Vol.268, No.14,pp.10553-10557
大海忍ほか著,細胞工学別冊 実験プロトコールシリーズ 抗ペプチド抗体実験プロトコール -ペプチド合成からタンパク質機能解析まで-,株式会社秀潤社,1994年 9月10日,pp.14-24
Mol. Reprod. Dev.,1993年,Vol.34, No.1,pp.53-57
Genet. Test,1997年,Vol.1, No.2,pp.125-129
Nucleic Acids Research,1990年,Vol.18, No.5,pp.1249-1254
Attorney, Agent or Firm:
Toshio Nishizawa
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