Title:
How to efficiently establish induced pluripotent stem cells
Document Type and Number:
Japanese Patent JP6366582
Kind Code:
B2
Abstract:
The present invention provides a method of improving iPS cell establishment efficiency, comprising contacting a protein involved in primitive streak (PrS) formation, preferably Foxh1, or a nucleic acid that encodes the same with a somatic cell in a nuclear reprogramming step. Also provided is a method of producing an iPS cell, comprising contacting the protein involved in PrS formation or a nucleic acid that encodes the same, and nuclear reprogramming substance(s) with a somatic cell.
Inventors:
Takahashi Kazutori
Takeshi Tanabe
Shinya Yamanaka
Takeshi Tanabe
Shinya Yamanaka
Application Number:
JP2015521172A
Publication Date:
August 01, 2018
Filing Date:
October 23, 2013
Export Citation:
Assignee:
Kyoto University
International Classes:
C12N5/10; C12N5/074; C12N15/11; C12N15/873
Domestic Patent References:
| JP2010537634A |
Foreign References:
| WO2010007031A1 | ||||
| WO2012141181A1 | ||||
| WO2007069666A1 | ||||
| WO2010117879A1 | ||||
| WO2012074117A1 |
Other References:
PNAS, 2006, Vol. 103, No. 45, pp. 16806-16811
Cell, 2006, Vol. 126, pp. 663-676
Cell, 2007, Vol. 131, pp. 861-872
Biology of reproduction, 2004, Vol. 71, pp. 1772-1778
Biochemical and Biophysical Research Communications, 2005, Vol. 330, pp. 934-942
International Journal of molecular medicine, 2006, Vol. 17, pp. 795-799
Stem Cells, 2004, Vol. 22, pp. 51-64
PLOS Computional Biology, 2011, Vol. 7, No. 12, e1002300
J.Neuroimmune.Pharmacol., 2012.Apr, Vol. 7, Suppl. 1, S58-S59
実験医学, 2010, Vol. 28, No. 3, pp. 378-382
Cell, 2006, Vol. 126, pp. 663-676
Cell, 2007, Vol. 131, pp. 861-872
Biology of reproduction, 2004, Vol. 71, pp. 1772-1778
Biochemical and Biophysical Research Communications, 2005, Vol. 330, pp. 934-942
International Journal of molecular medicine, 2006, Vol. 17, pp. 795-799
Stem Cells, 2004, Vol. 22, pp. 51-64
PLOS Computional Biology, 2011, Vol. 7, No. 12, e1002300
J.Neuroimmune.Pharmacol., 2012.Apr, Vol. 7, Suppl. 1, S58-S59
実験医学, 2010, Vol. 28, No. 3, pp. 378-382
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma