Title:
フェニルカルバメートを得る方法
Document Type and Number:
Japanese Patent JP2009503036
Kind Code:
A
Abstract:
The invention relates to a method of obtaining phenyl carbamates (I), wherein R 1 is lower alkyl C 1 -C 5 or benzyl and R 2 is methyl, ethyl or propyl, consisting in reacting L-(S)-3-[(1-methylamino)ethyl]phenol, in the presence of a base, with a carbamoyl halide in order to obtain an intermediate and, subsequently, subjecting said intermediate to a reducing amination reaction or a methylation reaction by reacting same with a methyl halide. The above-mentioned compounds (I) include rivastigmine, a compound that inhibits cholinesterase in the central nervous system, and can be used in the treatment of neurodegenerative diseases (E.g. senile dementia and Alzheimer's disease).
Inventors:
Murillo Gallido, Jose Vicente
Almengol Montserrat, Mikel
Martin Farres, Jorge
Almengol Montserrat, Mikel
Martin Farres, Jorge
Application Number:
JP2008524534A
Publication Date:
January 29, 2009
Filing Date:
August 03, 2006
Export Citation:
Assignee:
Intel Kim, Sociedad Anonima
International Classes:
C07C269/00; C07B57/00; C07C209/28; C07C213/02; C07C213/10; C07C215/50; C07C217/58; C07C269/06; C07C271/42; C07B61/00
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio