Title:
【発明の名称】タンパク質エージングを抑制するための改良された方法及び薬剤
Document Type and Number:
Japanese Patent JP2000509364
Kind Code:
A
Abstract:
The present invention relates to compositions and methods for inhibiting the aging of amino-containing amino acid, peptides, proteins and biomolecules. Accordingly, a composition is disclosed which comprises an agent or compound capable of reacting with the glycosyl-amino moiety of the early glycosylation product (also known as the Amadori product or the Heyns product) formed by the reaction of glucose, or other reactive sugars, with an amino-containing peptide, protein or biomolecule, thus stabilizing this early glycosylation product, and preventing its further reaction to form open-chain, carbonyl-containing advanced glycosylation end products. Suitable agents may contain a reactive aldehyde group. A preferred agent is acetaldehyde. The method comprises contacting the target biomolecule with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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Inventors:
Cerami Antony
Albedo joseph
Bucara Richard Jay
Ulric Petersea
Albedo joseph
Bucara Richard Jay
Ulric Petersea
Application Number:
JP51914197A
Publication Date:
July 25, 2000
Filing Date:
November 15, 1996
Export Citation:
Assignee:
The Picower Institute For Medical Research
International Classes:
A23L3/3562; A21D4/00; A61K31/00; A61K31/11; A61K38/00; A61K45/00; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/00; A61P13/12; A61P17/00; A61P19/00; A61P19/02; A61P25/00; A61P27/00; A61P27/02; A61P27/12; A61P43/00; C07H9/06; C07H19/01; G01N33/15; G01N33/50; G01N33/68; (IPC1-7): C07H19/01; A23L3/3562; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P17/00; A61P19/02; A61P25/00; A61P27/12; A61P27/02; A61P43/00; A61K45/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)