Title:
免疫系分子をヒト化する方法
Document Type and Number:
Japanese Patent JP2005537009
Kind Code:
A
Abstract:
Disclosed are methods for making immune system molecules, particularly humanized antibodies and fragments thereof. A typical method optimizes similarity between individual antibody framework regions to help identify human framework regions suitable for making the molecules. Comparisons between larger antibody frameworks, hypervariable domains or both is avoided. Also disclosed are antibodies that have been humanized by the method. The invention has a wide spectrum of applications including use in the production of humanized monoclonal antibodies with suitable binding affinity and minimized human immunogenicity.
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Inventors:
Wong Hin Si
Stinson Jeffrey Earl
Moscuella Luis A
Stinson Jeffrey Earl
Moscuella Luis A
Application Number:
JP2004532868A
Publication Date:
December 08, 2005
Filing Date:
August 06, 2003
Export Citation:
Assignee:
Snorr Molecular Corporation
International Classes:
C12N15/09; A61K39/395; C07K7/06; C07K7/08; C07K16/12; C07K16/18; C07K16/28; C07K16/30; C07K16/36; C07K16/46; C12P21/04; C12P21/08; (IPC1-7): C12P21/08; A61K39/395; C12N15/09
Domestic Patent References:
| JP2001509817A | 2001-07-24 | |||
| JPH04502408A | 1992-05-07 | |||
| JPH06508996A | 1994-10-13 |
Foreign References:
| US5498531A | 1996-03-12 | |||
| WO2002002143A2 | 2002-01-10 |
Other References:
JPN6009025562; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． Ｕ．Ｓ．Ａ． （１９９４） ｖｏｌ．９１， ｎｏ．２２， ｐ．１２０５１-１２０５５
JPN6009025561; Ｊ． Ｍｏｌ． Ｂｉｏｌ． （１９９２） ｖｏｌ．２２４， ｎｏ．２， ｐ．４８７-４９９
JPN6010062953; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． Ｕ．Ｓ．Ａ． （１９８９） ｖｏｌ．８６， ｎｏ．２４， ｐ．１００２９-１００３３
JPN6010062954; Ｅｕｒ． Ｊ． Ｉｍｍｕｎｏｌ． （１９９１） ｖｏｌ．２１， ｎｏ．１１， ｐ．２７１７-２７２５
JPN6011063730; Ｍｏｌ． Ｉｍｍｕｎｏｌ． （１９９５） ｖｏｌ．３２， ｎｏ．１７／１８， ｐ．１４１３-１４２７
JPN6011063731; Ｍｅｔｈｏｄｓ （２０００） ｖｏｌ．２０， ｎｏ．３， ｐ．２６７-２７９
JPN6011063730; Ｍｏｌ． Ｉｍｍｕｎｏｌ． （１９９５） ｖｏｌ．３２， ｎｏ．１７／１８， ｐ．１４１３-１４２７
JPN6010062954; Ｅｕｒ． Ｊ． Ｉｍｍｕｎｏｌ． （１９９１） ｖｏｌ．２１， ｎｏ．１１， ｐ．２７１７-２７２５
JPN6009025561; Ｊ． Ｍｏｌ． Ｂｉｏｌ． （１９９２） ｖｏｌ．２２４， ｎｏ．２， ｐ．４８７-４９９
JPN6010062953; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． Ｕ．Ｓ．Ａ． （１９８９） ｖｏｌ．８６， ｎｏ．２４， ｐ．１００２９-１００３３
JPN6010062954; Ｅｕｒ． Ｊ． Ｉｍｍｕｎｏｌ． （１９９１） ｖｏｌ．２１， ｎｏ．１１， ｐ．２７１７-２７２５
JPN6011063730; Ｍｏｌ． Ｉｍｍｕｎｏｌ． （１９９５） ｖｏｌ．３２， ｎｏ．１７／１８， ｐ．１４１３-１４２７
JPN6011063731; Ｍｅｔｈｏｄｓ （２０００） ｖｏｌ．２０， ｎｏ．３， ｐ．２６７-２７９
JPN6011063730; Ｍｏｌ． Ｉｍｍｕｎｏｌ． （１９９５） ｖｏｌ．３２， ｎｏ．１７／１８， ｐ．１４１３-１４２７
JPN6010062954; Ｅｕｒ． Ｊ． Ｉｍｍｕｎｏｌ． （１９９１） ｖｏｌ．２１， ｎｏ．１１， ｐ．２７１７-２７２５
Attorney, Agent or Firm:
Akitoshi Ota
Otawa Maki
Otawa Maki