Title:
シアリダーゼ阻害剤を用いた血小板の保存の改善法
Document Type and Number:
Japanese Patent JP2014515352
Kind Code:
A
Abstract:
The present invention relates to a platelet additive solution (PAS) having an amount of one or more sialidase inhibitors and optionally one or more glycan-modifying agents; and one or more of PAS components that includes a salt, a citrate source, a carbon source, and any combination thereof. The present invention also relates to methods, compositions and kits for increasing the in vivo circulation time of isolated platelets by storing the platelets with one or more sialidase inhibitors. Additionally, the present invention relates to methods and compositions for reducing sialidase activity and inhibiting bacterial proliferation of one or more bacteria in a platelet product preparation from one or more donors.
Inventors:
Ryu Kyon Peter
Hoffmeister Karin
Saxtain robert
Hoffmeister Karin
Saxtain robert
Application Number:
JP2014511561A
Publication Date:
June 30, 2014
Filing Date:
May 17, 2012
Export Citation:
Assignee:
Verico Medical Incorporated
The Brigham And Women's Hospital Incorporated
The Brigham And Women's Hospital Incorporated
International Classes:
A61K35/14; A01N1/02; A61K9/08; A61K31/7012; A61K35/19; A61K47/04; A61K47/12; A61K47/26; A61L33/00; A61P7/04; A61P43/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto