Title:
最終分化を誘導する方法
Document Type and Number:
Japanese Patent JP4732693
Kind Code:
B2
Abstract:
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.
Inventors:
Rishon, Victoria M.
Chiao, JHD
Miller, Thomas A
Kelly, Doubry Kevin
Chiao, JHD
Miller, Thomas A
Kelly, Doubry Kevin
Application Number:
JP2003574115A
Publication Date:
July 27, 2011
Filing Date:
March 04, 2003
Export Citation:
Assignee:
Merck HCD Research, LLC
Sloan-Kettering Institute for Cancer Research
Sloan-Kettering Institute for Cancer Research
International Classes:
A61K31/13; A61K9/48; A61K31/16; A61K31/167; A61K31/165; A61K31/19; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4706; A61K31/4709; A61K38/12; A61K47/12; A61K47/38; A61P35/00; A61P43/00; C07C259/04; G01N33/579
Domestic Patent References:
| JP7502494A |
Foreign References:
| WO2001018171A1 |
Other References:
OWEN A. O'Connor, et al.,Blood,2002年11月16日,Vol.100, No.11,p.4742
医薬品添加物ハンドブック,丸善株式会社,1989年,pp.274-276,「微結晶セルロース」の項
医薬品添加物ハンドブック,丸善株式会社,1989年,pp.167-170,「ステアリン酸マグネシウム」の項
医薬物添加物事典,株式会社薬事日報社,1994年,p.46,「クロスカルメロースナトリウム」の項
Adams, J. et al.,New agents in cancer clinical trials,Oncogene,2000年,Vol.19,pp.6687-6692
RICHON, V.M. et al.,PNAS,1996年,Vol.93,pp.5705-5708
医薬品添加物ハンドブック,丸善株式会社,1989年,pp.274-276,「微結晶セルロース」の項
医薬品添加物ハンドブック,丸善株式会社,1989年,pp.167-170,「ステアリン酸マグネシウム」の項
医薬物添加物事典,株式会社薬事日報社,1994年,p.46,「クロスカルメロースナトリウム」の項
Adams, J. et al.,New agents in cancer clinical trials,Oncogene,2000年,Vol.19,pp.6687-6692
RICHON, V.M. et al.,PNAS,1996年,Vol.93,pp.5705-5708
Attorney, Agent or Firm:
Kayo Shiina
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura