Title:
抗マラリヤ薬の製法
Document Type and Number:
Japanese Patent JP4083803
Kind Code:
B2
Abstract:
The invention relates to novel intermediates and processes for the preparation of quinoline compounds useful as anti-malarial drugs and novel intermediates useful in the process. A process for the preparation of a compound of formula (I) in which R1 is C1-6 alkyl; R2 and R3 are independently hydrogen, halogen, trifluoromethyl or C1-6 alkoxy; R4 is C1-6 alkyl; R5 is hydrogen or C1-6 alkyl; and R6 or amino which comprises reacting a compound of formula (II) in which R1, R4 and R5 are as defined in formula (I) and X is a leading group with a compound of formula (III).
Inventors:
Ugu Ugbrum, Cretas On Uzurike
Foy, James Edward
Foy, James Edward
Application Number:
JP51471997A
Publication Date:
April 30, 2008
Filing Date:
October 11, 1996
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
SMITHKLINE BEECHAM CORPORATION
SMITHKLINE BEECHAM CORPORATION
International Classes:
C07D215/22; A61K31/00; A61K31/47; A61K31/4706; A61P33/00; A61P33/06; C07D215/227; C07D215/40
Foreign References:
| US4431807 | ||||
| US4617394 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Mitsuo Tanaka