Title:
How to make cefquinome particles
Document Type and Number:
Japanese Patent JP6346144
Kind Code:
B2
Abstract:
Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. This enables providing particles of cefquinome acid addition salt, preferably cefquinome sulfate, in particle sizes commensurate with micronized material, but with improved stability.
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Inventors:
Niedermann, Hans Peter
Beaute, Heiko
Beaute, Heiko
Application Number:
JP2015200919A
Publication Date:
June 20, 2018
Filing Date:
October 09, 2015
Export Citation:
Assignee:
Interbet International B.Fee.
International Classes:
C07D501/46; A61K9/16; A61K31/546; A61K47/14; A61P31/04
Domestic Patent References:
| JP2006510607A | ||||
| JP8208662A | ||||
| JP1216995A | ||||
| JP2009885A | ||||
| JP63183590A | ||||
| JP5859436B2 |
Foreign References:
| WO2003063877A1 | ||||
| US20040115260 | ||||
| CN101050220A |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yoshikazu Iwase
Yasufumi Shiroyama