Title:
セフキノム粒子を製造する方法
Document Type and Number:
Japanese Patent JP2012533596
Kind Code:
A
Abstract:
Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. This enables providing particles of cefquinome acid addition salt, preferably cefquinome sulfate, in particle sizes commensurate with micronized material, but with improved stability.
Inventors:
Niedermann, Hans Peter
Beaute, Heiko
Beaute, Heiko
Application Number:
JP2012521010A
Publication Date:
December 27, 2012
Filing Date:
July 19, 2010
Export Citation:
Assignee:
Interventional Internal Bee
International Classes:
C07D501/56; A61K9/10; A61K31/546; A61K47/14; A61P31/04
Domestic Patent References:
| JPH01216995A | 1989-08-30 | |||
| JPH029885A | 1990-01-12 | |||
| JPS63183590A | 1988-07-28 | |||
| JPH08208662A | 1996-08-13 | |||
| JP2006510607A | 2006-03-30 | |||
| JPH01216995A | 1989-08-30 | |||
| JPH029885A | 1990-01-12 | |||
| JPS63183590A | 1988-07-28 |
Foreign References:
| CN101050220A | 2007-10-10 | |||
| US20040115260A1 | 2004-06-17 | |||
| WO2003063877A1 | 2003-08-07 | |||
| CN101050220A | 2007-10-10 |
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama