Title:
Ｔ細胞療法用のＴ細胞を調製する方法
Document Type and Number:
Japanese Patent JP6952029
Kind Code:
B2
Abstract:
Provided herein are methods for delaying or inhibiting T cell maturation or differentiationin vitrofor a T cell therapy, comprising contacting one or more T cells from a subject in need of a T cell therapy with an AKT inhibitor and at least one of exogenous Interleukin-7 (IL-7) and exogenous Interleukin-15 (IL-15), wherein the resulting T cells exhibit delayed maturation or differentiation. In some embodiments, the method further comprises administering the one or more T cells to a subject in need of a T cell therapy.
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Inventors:
Perez Arianne
Sabatino marianna
Rosenberg Steven A.
Restifo Nicolas Peas.
Sabatino marianna
Rosenberg Steven A.
Restifo Nicolas Peas.
Application Number:
JP2018520185A
Publication Date:
October 20, 2021
Filing Date:
October 20, 2016
Export Citation:
Assignee:
Kite Pharma, Inc
International Classes:
C12N5/0783; A61K35/17; A61P35/00; A61P35/02; C12N5/10; C12N15/12; C12N15/867
Foreign References:
| US20130045491 | ||||
| WO2012177925A1 |
Other References:
Blood[インターネット],2013年11月15日,Volume 122, Issue 21,p. 3269,https://doi.org/10.1182/blood.V122.21.3269.3269,令和2年11月12日検索
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office