Title:
【発明の名称】β―ラクタム抗生物質を調製する方法
Document Type and Number:
Japanese Patent JP2000512860
Kind Code:
A
Abstract:
The invention relates to a method for preparing a beta-lactam antibiotic, wherein an N-substituted beta-lactam, having general formula (I), wherein R0 is hydrogen or C1-3 alkoxy; Y is CH2, oxygen, sulfur, or an oxidized form of sulfur; Z is (a), (b), (c) or (d), wherein R1 is hydrogen, hydroxy, halogen, C1-3 alkoxy, optionally substituted, optionally containing one or more heteroatoms, saturated or unsaturated, branched or straight C1-5 alkyl, preferably methyl, optionally substituted, optionally containing one or more heteroatoms C5-8 cycloalkyl, optionally substituted aryl or heteroaryl, or optionally substituted benzyl; and X is (CH2)m-A-(CH2)n, wherein m and n are the same or different and are chosen from the group of integers 0, 1, 2, 3 or 4 and A is CH=CH, C=C, CHB, C=O, optionally substituted nitrogen, oxygen, sulfur or an optionally oxidized form of sulfur, and B is hydrogen, halogen, hydroxy, C1-3 alkoxy, or optionally substituted methyl, or a salt thereof, is contacted with at least one dicarboxylate acylase, or a functional equivalent thereof, and reacted with a precursor for a side chain of the beta-lactam antibiotic in the presence of at least one penicillin acylase, or a functional equivalent thereof.
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Inventors:
Van der douse thomas
De Frome Eric
Kapoor Jagdish Chandler
De Frome Eric
Kapoor Jagdish Chandler
Application Number:
JP54504398A
Publication Date:
October 03, 2000
Filing Date:
April 22, 1998
Export Citation:
Assignee:
Gist Brocades Besloten Fennaught Shap
International Classes:
C12P35/02; C12P35/04; C12P37/02; C12P37/04; C12P37/06; (IPC1-7): C12P37/04; C12P35/04; C12P37/02
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)