Title:
リポ酸およびジヒドロリポ酸の調製方法
Document Type and Number:
Japanese Patent JP2004514716
Kind Code:
A
Abstract:
The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO2-R' and R and R' independently of one another are C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.
Inventors:
Krat, martin, yochen
Nibel, Marx
Pawst, Joachim
Nibel, Marx
Pawst, Joachim
Application Number:
JP2002546533A
Publication Date:
May 20, 2004
Filing Date:
November 29, 2001
Export Citation:
Assignee:
BASF Aktiengesellschaft
International Classes:
C07D339/04; (IPC1-7): C07D339/04
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ai Fujii
Satoshi Fujita
Ai Fujii