Title:
カルバペネム系抗生物質組成物の処方方法
Document Type and Number:
Japanese Patent JP4854899
Kind Code:
B2
Abstract:
A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula (II). The process entails compounding an unstable, monosodium salt carbapenem with a sodium bicarbonate solution at a temperature range of from about 0 DEG to about 5 DEG C while maintaining a pH between about 7.0 and about 8.0, filtering the resultant solution, bottling under sterile conditions, and lyophilizing to produce the formulation.
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Inventors:
Al-Daney, Anthony
Hank, William A
Irig, Kathleen Jay
Kanike, Anand
Patel, Hiren
Reynolds, Scott Day
Twinon Chidous, Stelios Sea
Hank, William A
Irig, Kathleen Jay
Kanike, Anand
Patel, Hiren
Reynolds, Scott Day
Twinon Chidous, Stelios Sea
Application Number:
JP2001534377A
Publication Date:
January 18, 2012
Filing Date:
October 27, 2000
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
A61K9/19; A61P31/04; A61K31/407; C07D477/02; C07D477/20
Domestic Patent References:
| JP11509871A |
Foreign References:
| US5952323A | 1999-09-14 | |||
| WO1998018800A1 | 1998-05-07 | |||
| WO1998057973A1 | 1998-12-23 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Katsuma Osaki
Takamasa Soma
Mitsuru Inoue
Akio Ichiiri
Katsuma Osaki
Takamasa Soma