Title:
How to reduce condensation of IL-1ra
Document Type and Number:
Japanese Patent JP6181375
Kind Code:
B2
Abstract:
Methods of reducing aggregation of an aggregating IL-1ra comprising incubating IL-1ra with at least one accessory molecule are provided. Kits comprising IL-1ra and at least one accessory molecule are also provided. Pharmaceutical compositions comprising IL-1ra and at least one accessory molecule are also provided.
Inventors:
Andrey Reybekas
Bruce Carwin
Bruce Carwin
Application Number:
JP2013011368A
Publication Date:
August 16, 2017
Filing Date:
January 24, 2013
Export Citation:
Assignee:
Swedish Orphan Biovitrum Arbe (Pou Beer)
International Classes:
A61K38/00; A61K9/00; A61K9/08; A61K31/655; A61K31/7012; A61K33/42; A61K38/17; A61K38/20; A61K47/02; A61K47/10; A61K47/12; A61K47/24; A61K47/26; A61P19/02; A61P29/00; C07H21/04; C07K14/54; C07K14/545; C12P21/06
Domestic Patent References:
| JP8504755A | ||||
| JP2001500472A | ||||
| JP2001500876A | ||||
| JP2003510368A |
Other References:
Byeong S. Chang, et al.,ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,米国,1996年 7月15日,V331 N2,P249-258
Byeong S. Chang, et al.,PHARMACEUTICAL RESEARCH,米国,1996年2月 1日,V13 N2,P243-249
Byeong S. Chang, et al.,Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution,Biophys J,1996年,Vol.71, No.6,p.3399-406
Albert Light,Protein Solubility, Protein Modifications and Protein Folding,BioTechniques,1985年,3(4),298-306
Byeong S. Chang, et al.,PHARMACEUTICAL RESEARCH,米国,1996年2月 1日,V13 N2,P243-249
Byeong S. Chang, et al.,Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution,Biophys J,1996年,Vol.71, No.6,p.3399-406
Albert Light,Protein Solubility, Protein Modifications and Protein Folding,BioTechniques,1985年,3(4),298-306
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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