Title:
METHODS OF REDUCING OR ELIMINATING PROTEIN MODIFICATION AND DEGRADATION ARISING FROM EXPOSURE TO UV LIGHT
Document Type and Number:
Japanese Patent JP2017061462
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods of inactivation of a virus in a sample comprising a protein component.SOLUTION: Provided is a method comprising, in a sample comprising a protein component wherein the sample is known or suspected to contain a virus, identifying a target dose of UV light under which the virus is inactivated; adding a protectant to the sample to form a stabilized mixture; exposing the stabilized mixture to UV light provided by a source operating at a selected power level and selected wavelength for a selected period of time; assessing the UV-C exposure level of the stabilized mixture; and modulating one or more of the wavelength, the UV light source power and the UV light exposure time if the assessment indicates the target dose of UV light has not been delivered to the stabilized mixture.SELECTED DRAWING: Figure 14
Inventors:
JOSEPH EDWARD SHULTZ
ROGER HART
BRENT WELBORN
ROGER HART
BRENT WELBORN
Application Number:
JP2016197842A
Publication Date:
March 30, 2017
Filing Date:
October 06, 2016
Export Citation:
Assignee:
AMGEN
International Classes:
C07K1/14
Domestic Patent References:
| JP2008510538A | 2008-04-10 | |||
| JPH0758031A | 1995-03-03 | |||
| JP2003511148A | 2003-03-25 | |||
| JP2004520448A | 2004-07-08 |
Foreign References:
| WO2011004285A1 | 2011-01-13 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office