Title:
置換フェネチルスルホン類およびTNFαレベルの減少方法
Document Type and Number:
Japanese Patent JP4530543
Kind Code:
B2
Abstract:
Phenethylsulfones substituted alpha to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline reduce the levels of TNF alpha in a mammal. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-aminoisoindoline-1,3-dione.
Inventors:
Man, Hong-wa
Muller, George
Muller, George
Application Number:
JP2000579218A
Publication Date:
August 25, 2010
Filing Date:
October 19, 1999
Export Citation:
Assignee:
Celgene Corporation
International Classes:
A61K31/4035; C07D209/46; A61K31/403; A61P1/00; A61P7/08; A61P19/02; A61P25/00; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07D209/48; C07D209/68; C07D217/24; C07D275/06
Domestic Patent References:
| JP9500872A |
Foreign References:
| WO1997023457A1 | ||||
| US5728844 |
Other References:
C.G.WERMUTH 編, 長瀬博 監訳,最新 創薬化学 上巻,株式会社 テクノミック,1998年 8月15日,p.248-249
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Mami Hino
Yasuhito Suzuki
Atsushi Nogami
Etsuko Saito
Eiji Katayama
Norio Omori
Mami Hino
Yasuhito Suzuki
Atsushi Nogami
Etsuko Saito