Title:
TOLL関連レセプター(TRR)シグナル伝達の調節方法
Document Type and Number:
Japanese Patent JP2004522432
Kind Code:
A
Abstract:
We describe (1) a method of enhancing antigen presentation, comprising the step of supplying to an antigen presenting cell such as a dendritic cell, or precursor cell, an inhibitor of Toll-related receptor (TRR) signalling and (2) a method of inhibiting antigen presentation, comprising the step of supplying to an antigen presenting cell such as a dendritic cell, or precursor cell, an enhancer of Toll-related receptor (TRR) signalling. The inhibitor of TRR signalling may be a dominant negative mutant of MyD88, for example MyD881pr.
Inventors:
Foxwell, Bryan, Maurice, John
Mark Feldman
Mark Feldman
Application Number:
JP2002552572A
Publication Date:
July 29, 2004
Filing Date:
December 21, 2001
Export Citation:
Assignee:
Synovis Limited
International Classes:
G01N33/50; A61K38/17; A61K39/00; A61K39/39; A61K45/00; A61K48/00; A61P31/12; A61P35/00; A61P37/02; C12N5/0784; C12N15/09; C12Q1/68; G01N33/15; (IPC1-7): C12N15/09; A61K39/00; A61K39/39; A61K45/00; A61K48/00; C12Q1/68; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Yoshinori Hosoda